التفاصيل البيبلوغرافية
| العنوان: |
SYSTEM AND METHOD FOR PREDICTION AND DETECTION OF CIRCULATORY SHOCK |
| Document Number: |
20080287753 |
| تاريخ النشر: |
November 20, 2008 |
| Appl. No: |
12/122247 |
| Application Filed: |
May 16, 2008 |
| مستخلص: |
Systems and methods for prediction and detection of circulatory shock using estimates or measurements of arterial blood pressure, heart rate, stroke volume, cardiac output, total peripheral resistance, cardiac ejection fraction, cardiac contractility and ventricular end-diastolic volume are provided. These estimates and measurements are used to determine a type of circulatory shock. In some embodiments, the type of circulatory shock is determined to be one of septic shock, hypovolemic shock, anaphylactic shock, hemorrhagic shock, and cardiogenic shock. |
| Inventors: |
Parlikar, Tushar A. (Cambridge, MA, US); Heldt, Thomas (Cambridge, MA, US); Verghese, George C. (Newton, MA, US); Mark, Roger Greenwood (Cambridge, MA, US) |
| Claim: |
1. A system for predicting or detecting circulatory shock, comprising: a blood pressure measuring device; a processor; a display; a user interface; and a memory storing computer-executable instructions, which when executed by the processor cause the processor to: receive measurements of arterial blood pressure from the blood pressure measuring device; compute mean arterial blood pressure from the received arterial blood pressure measurements; receive or compute estimates of at least one of heart rate, total peripheral resistance, stroke volume, cardiac output, ejection fraction, ventricular end-diastolic volume, and cardiac contractility; predict or detect a type of circulatory shock based in part on one or more of the received measurements and the received or computed estimates. |
| Claim: |
2. The system of claim 1, further comprising an electrocardiogram device. |
| Claim: |
3. The system of claim 1, wherein the computer-executable instructions, when executed by the processor, cause the processor to display at least one of the received measurements and the received or computed estimates. |
| Claim: |
4. The system of claim 1, wherein the computer-executable instructions, when executed by the processor, cause the processor to display the type of circulatory shock. |
| Claim: |
5. The system of claim 1, wherein the type of circulatory shock is determined to be one of septic shock, hypovolemic shock, anaphylactic shock, hemorrhagic shock, and cardiogenic shock. |
| Claim: |
6. The system of claim 1, wherein the received or computed estimates are each classified as low, normal or high. |
| Claim: |
7. The system of claim 6, wherein the type of circulatory shock is determined to be one of septic shock, hypovolemic shock, anaphylactic shock, hemorrhagic shock, and cardiogenic shock. |
| Claim: |
8. The system of claim 7, wherein the type of circulatory shock is determined to be: (A) septic shock if the mean arterial blood pressure is low, total peripheral resistance is low, heart rate is high, ejection fraction is normal or high, cardiac output is low or high. (B) hypovolemic shock if the mean arterial blood pressure is low, total peripheral resistance is high, heart rate is high, ejection fraction is normal or high, end-diastolic volume is low, cardiac output is low or high. (C) anaphylactic shock if the mean arterial blood pressure is low, total peripheral resistance is low, heart rate is high, ejection fraction is normal or high, cardiac output is high. (D) hemorrhagic shock if the mean arterial blood pressure is low, total peripheral resistance is high, heart rate is high, ejection fraction is normal or high, end-diastolic volume is low, cardiac output is low or high.; and (E) cardiogenic shock if the mean arterial blood pressure is low, total peripheral resistance is high, ejection fraction is low, end-diastolic volume is high, cardiac output is low. |
| Claim: |
9. The system of claims 1, 5, 7, or 8, wherein the determination is done using a lookup table. |
| Claim: |
10. The system of claims 1, 5, 7, or 8, wherein the determination is done using population-specific data. |
| Claim: |
11. The system of claims 1, 5, 7, or 8, wherein the determination is done using patient-specific data. |
| Claim: |
12. The system of claims 1, 5, 7, or 8, wherein the determination is done using a machine learning algorithm. |
| Claim: |
13. The system of claim 12, wherein the machine learning algorithm includes a Bayesian network. |
| Claim: |
14. The system of claim 12, wherein the machine learning algorithm includes a neural network. |
| Claim: |
15. The system of claim 12, wherein the machine learning algorithm includes a fuzzy logic model. |
| Claim: |
16. The system of claim 1, wherein the blood pressure measuring device is a noninvasive blood pressure measuring device. |
| Claim: |
17. The system of claim 17, wherein the noninvasive blood pressure measuring device is a photoplethysmographic blood pressure measuring device. |
| Claim: |
18. The system of claim 17, wherein the noninvasive blood pressure measuring device is a tonometric blood pressure measuring device. |
| Claim: |
19. The system of claim 1, wherein the arterial blood pressure is measured at a central artery of the cardiovascular system. |
| Claim: |
20. The system of claim 1, wherein the arterial blood pressure is measured at a peripheral artery of the cardiovascular system. |
| Claim: |
21. The system of claim 1, wherein the arterial blood pressure is measured at a pulmonary artery of the cardiovascular system. |
| Claim: |
22. The system of claim 1, wherein the received or computed estimates are uncalibrated estimates. |
| Claim: |
23. A method for predicting or detecting circulatory shock, the method comprising: receiving measurements of arterial blood pressure; computing mean arterial blood pressure from the received arterial blood pressure measurements; receiving or computing estimates of at least one of heart rate, total peripheral resistance, stroke volume, cardiac output, ejection fraction, ventricular end-diastolic volume, and cardiac contractility; and predicting or detecting a type of circulatory shock based in part on one or more of the received measurements and the received or computed estimates. |
| Claim: |
24. The method of claim 23, further comprising receiving electrocardiograph measurements. |
| Claim: |
25. The method of claim 23, further comprising displayed at least one of the received measurements and the received or computed estimates. |
| Claim: |
26. The method of claim 23, further comprising displaying the type of circulatory shock. |
| Claim: |
27. The method of claim 23, wherein the type of circulatory shock is determined to be one of septic shock, hypovolemic shock, anaphylactic shock, hemorrhagic shock, and cardiogenic shock. |
| Claim: |
28. The method of claim 23, wherein the received or computed estimates are each classified as low, normal or high. |
| Claim: |
29. The method of claim 28, wherein the type of circulatory shock is determined to be one of septic shock, hypovolemic shock, anaphylactic shock, hemorrhagic shock, and cardiogenic shock. |
| Claim: |
30. The method of claim 29, wherein the type of circulatory shock is determined to be: (A) septic shock if the mean arterial blood pressure is low, total peripheral resistance is low, heart rate is high, ejection fraction is normal or high, cardiac output is low or high. (B) hypovolemic shock if the mean arterial blood pressure is low, total peripheral resistance is high, heart rate is high, ejection fraction is normal or high, end-diastolic volume is low, cardiac output is low or high. (C) anaphylactic shock if the mean arterial blood pressure is low, total peripheral resistance is low, heart rate is high, ejection fraction is normal or high, cardiac output is high. (D) hemorrhagic shock if the mean arterial blood pressure is low, total peripheral resistance is high, heart rate is high, ejection fraction is normal or high, end-diastolic volume is low, cardiac output is low or high.; and (E) cardiogenic shock if the mean arterial blood pressure is low, total peripheral resistance is high, ejection fraction is low, end-diastolic volume is high, cardiac output is low. |
| Claim: |
31. The method of claims 23, 27, 29, or 30, wherein the determination is done using a lookup table. |
| Claim: |
32. The method of claims 23, 27, 29, or 30, wherein the determination is done using population-specific data. |
| Claim: |
33. The method of claims 23, 27, 29, or 30, wherein the determination is done using patient-specific data. |
| Claim: |
34. The method of claims 23, 27, 29, or 30, wherein the determination is done using a machine learning algorithm. |
| Claim: |
35. The method of claim 34, wherein the machine learning algorithm includes a Bayesian network. |
| Claim: |
36. The method of claim 34, wherein the machine learning algorithm includes a neural network. |
| Claim: |
37. The method of claim 34, wherein the machine learning algorithm includes a fuzzy logic model. |
| Claim: |
38. The method of claim 23, wherein the arterial blood pressure is central arterial blood pressure. |
| Claim: |
39. The method of claim 23, wherein the arterial blood pressure is peripheral arterial blood pressure. |
| Claim: |
40. The method of claim 23, wherein the arterial blood pressure is pulmonary arterial blood pressure. |
| Claim: |
41. The method of claim 23, wherein the received or computed estimates are uncalibrated estimates. |
| Current U.S. Class: |
600/301 |
| Current International Class: |
61; 61 |
| رقم الانضمام: |
edspap.20080287753 |
| قاعدة البيانات: |
USPTO Patent Applications |