| Claim: |
2. An HIV integrase inhibitor compound of claim 1 comprising one or more covalently attached A0 groups; wherein: A0 is A1, A2 or W3; [chemical expression included] where: Y1 is independently O, S, NRx, N(O)(Rx), N(ORx), N(O)(ORx), or N(N(Rx)2); Y2 is independently a bond, O, NRx, N(O)(Rx), N(ORx), N(O)(ORx), N(N(Rx)2), S(O) (sulfoxide), S(O)2 (sulfone), S (sulfide), or S—S (disulfide); M2 is 0, 1 or 2; M12a is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12; and M12b is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12; Ry is independently H, C1-C18 alkyl, C1-C18 substituted alkyl, C2-C18 alkenyl, C2-C18 substituted alkenyl, C2-C18 alkynyl, C2-C18 substituted alkynyl, C6-C20 aryl, C6-C20 substituted aryl, or a protecting group, or where taken together at a carbon atom, two vicinal Ry groups form a carbocycle or a heterocycle; or taken together at a carbon atom, two vicinal Ry groups form a ring; such as, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl; or the ring may contain one or more heteroatoms forming a heterocyclic ring such as, piperazinyl, piperidinyl, pyranyl, or tetrahydrofuryl; Rx is independently H, C1-C18 alkyl, C1-C18 substituted alkyl, C2-18 alkenyl, C2-C18 substituted alkenyl, C2-C18 alkynyl, C2-C18 substituted alkynyl, C6-20 aryl, C6-20 substituted aryl, or a protecting group, or the formula: [chemical expression included] where M1a, M1c, and M1d are independently 0 or 1, and M12c is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12; W3 is W4 or W5; W4 is R5, —C(Y1)R5, —C(Y1)W5, —SO2R5, or —SO2W5 W5 is a carbocycle or a heterocycle wherein W5 is independently substituted with 0 to 3 R2 groups; W3a is W4a or W5a; W4a is R5a, —C(Y1)R5a, —C(Y1)W5a, —SO2R5a, or —SO2W5a; W5a is a multivalent substituted carbocycle or heterocycle wherein W5a is independently substituted with 0 to 3 R2 groups; W6 is W3a independently substituted with 1, 2, or 3 A3 groups; R1 is independently H or alkyl of 1 to 18 carbon atoms; R2 is independently H, R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups; or taken together at a carbon atom, two R2 groups form a ring; such as, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl; optionally, the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is F, Cl, Br, I, —CN, N3 or —NO2; R3b is Y1; R3c is —Rx, —N(Rx)2—SRx, —S(O)Rx, —S(O)2Rx, —S(O)(ORx), —S(O)2(ORx), —OC(Y1)Rx, —OC(Y)ORx, —OC(Y1)N(Rx)2, —SC(Y1)Rx, —SC(Y1)ORx, SC(Y1)N(Rx)2, —N(Rx)C(Y1)Rx, —N(Rx)C(Y1)ORx, or —N(Rx)C(Y1)N(Rx)2; R3d is —C(Y1)Rx, —C(Y1)ORx or —C(Y1)N(Rx)2; R4 is an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R5 is R4 wherein each R4 is substituted with 0 to 3 R3 groups; and R5a is independently alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2-18 carbon atoms any one of which alkylene, alkenylene or alkynylene is substituted with 0-3 R3 groups; R is independently selected from H, C1-C18 alkyl, C1-C18 substituted alkyl, C2-C18 alkenyl, C2-C18 substituted alkenyl, C2-C18 alkynyl, C2-C18 substituted alkynyl, C6-20 aryl, C6-C20 substituted aryl, C2-C20 heterocycle, C2-C20 substituted heterocycle, phosphonate, phosphate, polyethyleneoxy, a protecting group, L-A3, and a prodrug moiety; Substituted alkyl, substituted alkenyl, substituted alkynyl, substituted aryl, and substituted heterocycle are independently substituted with one or more substituents selected from F, Cl, Br, I, OH, amino (—NH2), ammonium (—NH3+), alkylamino (—NHR), dialkylamino (—NR2), trialkylammonium (—NR3+), C1-C8 alkyl, C1-C8 alkylhalide, carboxylate, thiol (—SH), sulfate (—OSO3R), sulfamate, sulfonate (—SO3R), 5-7 membered ring sultam, C1-C8 alkylsulfonate, C1-C8 alkylamino, 4-dialkylaminopyridinium, C1-C8 alkylhydroxyl, C1-8 alkylthiol, alkylsulfone (—SO2R), arylsulfone (—SO2Ar), arylsulfoxide (—SOAr), arylthio (—SAr), sulfonamide (—SO2NR2), alkylsulfoxide (—SOR), ester (—COOR), amido (—C(═O)NR2), 5-7 membered ring lactam, 5-7 membered ring lactone, nitrile (—CN), azido (—N3), nitro (—NO2), C1-C18 alkoxy (—OR), C1-C8 alkyl, C1-C8 substituted alkyl, C6-C20 aryl, C6-C20 substituted aryl, C2-C20 heterocycle, and C2-C20 substituted heterocycle, phosphonate, phosphate, polyethyleneoxy, and a prodrug moiety; and L is a bond, O, S, SS (disulfide), S(═O) (sulfoxide), S(═O)2 (sulfone), —S(═O)2N(R)— (sulfonamide), NR, N—OR, C1-C12 alkylene, C1-C12 substituted alkylene, C2-C12 alkenylene, C2-C12 substituted alkenylene, C2-C12 alkynylene, C2-C12 substituted alkynylene, —(CR2)nO(CR2)n—, —C(═O)NH—, —OC(═O)NH—, —NHC(═O)NH—, C(═O), —C(═O)NH(CH2)n—, or —(CH2CH2O)n—, where n may be 1, 2, 3, 4, 5, or 6; wherein at least one A0 group is an A1 group. |