التفاصيل البيبلوغرافية
| العنوان: |
Cardiac muscle regeneration using mesenchymal stem cells |
| Document Number: |
20070003530 |
| تاريخ النشر: |
January 4, 2007 |
| Appl. No: |
11/475568 |
| Application Filed: |
June 23, 2006 |
| مستخلص: |
Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation. |
| Inventors: |
Pittenger, Mark F. (Severna Park, MD, US); Gordon, Stephen L. (Columbia, MD, US); Mackay, Alastair Morgan (Timonium, MD, US); Martin, Bradley J. (Ellicott City, MD, US) |
| Claim: |
1-53. (canceled) |
| Claim: |
54. A process for treating a patient with damaged heart muscle to improve heart function, comprising: treating said patient to improve heart function by administering to said patient mesenchymal stem cells in an amount effective to improve heart function. |
| Claim: |
55. The process of claim 54 wherein the mesenchymal stem cells are administered directly to the heart. |
| Claim: |
56. The process of claim 55 wherein the mesenchymal stem cells are administered by injection. |
| Current U.S. Class: |
424093/210 |
| Current International Class: |
61 |
| رقم الانضمام: |
edspap.20070003530 |
| قاعدة البيانات: |
USPTO Patent Applications |