التفاصيل البيبلوغرافية
| العنوان: |
Thiophene-and thiazolesulfonamides as antineoplastic agents |
| Document Number: |
20060223871 |
| تاريخ النشر: |
October 5, 2006 |
| Appl. No: |
11/447457 |
| Application Filed: |
June 06, 2006 |
| مستخلص: |
The present invention provides antineoplastic compounds of the formula: [chemical expression included] and antineoplastic methods. |
| Inventors: |
Grossman, Cora Sue (Indianapolis, IN, US); Hipskind, Philip Arthur (New Palestine, IN, US); Lin, Ho-Shen (Indianapolis, IN, US); Lobb, Karen Lynn (Indianapolis, IN, US); Lopez de Uralde Garmendia, Beatriz (Madrid, ES); Lopez, Jose Eduardo (Fishers, IN, US); Mader, Mary Margaret (Fishers, IN, US); Richett, Michael Enrico (Indianapolis, IN, US); Shih, Chuan (Carmel, IN, US); De Dios, Alfonso (Madrid, ES) |
| Claim: |
1-17. (canceled) |
| Claim: |
18. A method of treating a susceptible neoplasm selected from the group consisting of metastatic soft tissue sarcoma, non-small cell lung cancer, melanoma, ovarian cancer, breast cancer, leukemia, lymphoma, renal cancer, prostate cancer, and multiple myeloma in a mammal comprising administering to a mammal in need of such treatment an oncolytically effective amount of a compound of Formula I: [chemical expression included] where: [chemical expression included] R1 is selected from the group consisting of halo, C1-C6 alkyl, and CF3; R2 is selected from the group consisting of halo, —NO2, C1-C6 alkyl, and CF3; R3′ is H, C1-C6 alkyl, C1-C4 alkoxy, C1-C6 alkylthio, or halo; R4′ is selected from the group consisting of H, halo, C1-C4 alkoxy, —COO(C1-C6 alkyl), C1-C6 alkyl optionally substituted with C1-C4 alkoxy, cyano, C1-C6 alkylthio, CF3, S-phenyl, and pyridinyl; R5 is halo, C1-C6 alkyl, or C1-C4 alkoxy; or a pharmaceutically acceptable base addition salt thereof. |
| Claim: |
19. The method of claim 18 wherein the compound is N-[2,4-dichlorobenzoyl]-5-bromothiophene-2-sulfonamide or a pharmaceutically acceptable base addition salt thereof. |
| Claim: |
20. The method of claim 19 wherein the compound is N-[2,4-dichlorobenzoyl]-5-bromothiophene-2-sulfonamide sodium salt. |
| Claim: |
21. The method of claim 18 wherein the susceptible neoplasm is selected from the group consisting of metastatic soft tissue sarcoma, non-small cell lung cancer, melanoma, and ovarian cancer. |
| Claim: |
22. The method of claim 21 wherein the compound is N-[2,4-dichlorobenzoyl]-5-bromothiophene-2-sulfonamide or a pharmaceutically acceptable base addition salt thereof. |
| Claim: |
23. The method of claim 22 wherein the compound is N-[2,4-dichlorobenzoyl]-5-bromothiophene-2-sulfonamide sodium salt. |
| Current U.S. Class: |
514369/000 |
| Current International Class: |
61; 61; 07 |
| رقم الانضمام: |
edspap.20060223871 |
| قاعدة البيانات: |
USPTO Patent Applications |