Academic Journal
Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection.
| العنوان: | Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection. |
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| المؤلفون: | Rodger, Alison J, Fox, Zoe, Lundgren, Jens D, Kuller, Lewis H, Boesecke, Christoph, Gey, Daniela, Skoutelis, Athanassios, Goetz, Matthew Bidwell, Phillips, Andrew N |
| المساهمون: | Moutschen, Michel |
| المصدر: | Journal of Infectious Diseases, 200 (6), 973-83 (2009) |
| بيانات النشر: | University of Chicago Press, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | AIDS-Related Opportunistic Infections/metabolism, Adult, Anti-HIV Agents, Biological Markers, Blood Coagulation/physiology, C-Reactive Protein/metabolism, Case-Control Studies, Female, Humans, Inflammation/metabolism, Interleukin-6/metabolism, Male, Middle Aged, Odds Ratio, Risk Factors, Serum Amyloid A Protein/metabolism, Serum Amyloid P-Component/metabolism, Human health sciences, Immunology & infectious disease, Sciences de la santé humaine, Immunologie & maladie infectieuse |
| الوصف: | BACKGROUND: Activation and coagulation biomarkers were measured within the Strategies for Management of Antiretroviral Therapy (SMART) trial. Their associations with opportunistic disease (OD) in human immunodeficiency virus (HIV)-positive patients were examined. METHODS: Inflammatory (high-sensitivity C-reactive protein [hsCRP], interleukin-6 [IL-6], amyloid-A, and amyloid-P) and coagulation (D-dimer and prothrombin-fragment 1+2) markers were determined. Conditional logistic regression analyses were used to assess associations between these biomarkers and risk of OD. RESULTS: The 91 patients who developed an OD were matched to 182 control subjects. Patients with an hsCRP level > or =5 microg/mL at baseline had a 3.5 higher odds of OD (95% confidence interval [CI], 1.5-8.1) than did those with an hsCRP level <1 microg/mL (P=.003, by test for trend) and patients with an IL-6 level > or =3 pg/mL at baseline had a 2.4 higher odds of OD (95% CI, 1.0-5.4) than did those with an IL-6 level <1.5 pg/mL (P=.02, by test for trend). No other baseline biomarkers predicted development of an OD. Latest follow-up hsCRP level for those with an hsCRP level > or =5 microg/mL (compared with a level <1 microg/mL; odds ratio [OR], 7.6; 95% CI, 2.0-28.5; [P=.002, by test for trend), latest amyloid-A level for those with an amyloid-A level > or =6 mg/L (compared with a level <2 mg/L; OR, 3.8; 95% CI, 1.1-13.4; P=.03, by test for trend), and latest IL-6 level for those with an IL-6 level > or =3 pg/mL (compared with a level <1.5 pg/mL; OR 2.4; 95% CI, 0.7-8.8; P=.04, by test for trend) were also associated with development of an OD. CONCLUSIONS: Higher IL-6 and hsCRP levels independently predicted development of OD. These biomarkers could provide additional prognostic information for predicting the risk of OD. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | urn:issn:0022-1899; urn:issn:1537-6613 |
| DOI: | 10.1086/605447 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/71234 |
| Rights: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.71234 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1086/605447 |
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