Academic Journal
Inhibition des recepteurs CB1 et metabolisme du glucose: rimonabant dans le diabete de type 2.
| العنوان: | Inhibition des recepteurs CB1 et metabolisme du glucose: rimonabant dans le diabete de type 2. CB1 receptor inhibition and glucose metabolism: role of rimonabant in type 2 diabetes |
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| المؤلفون: | Scheen, André, Paquot, Nicolas, Van Gaal, Luc F |
| المصدر: | Revue Médicale Suisse, 4 (168), 1812-7 (2008) |
| بيانات النشر: | Medecine et Hygiène, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Blood Glucose/metabolism, Diabetes Mellitus, Type 2/drug therapy/metabolism, Humans, Hypoglycemic Agents/therapeutic use, Piperidines/therapeutic use, Pyrazoles/therapeutic use, Receptor, Cannabinoid, CB1/antagonists & inhibitors/metabolism, Human health sciences, Endocrinology, metabolism & nutrition, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition |
| الوصف: | Endocannabinoid system is overactivated in individuals with abdominal obesity. CBI receptors, first individualized in the brain, are also expressed in the adipocyte, the skeletal muscle, the liver, the gut, and the pancreas. Their blockade improves glucose tolerance and lipid profile, thanks increased insulin sensitivity and adiponectin levels. Rimonabant, a selective antagonist of CBI receptors, improves glucose control in patients with type 2 diabetes, treated with diet alone, metformin, sulfonylurea or insulin, while it also reduces body weight and other risk factors. Ongoing studies aim at further demonstrating the potential of rimonabant in the management of type 2 diabetes, in the prevention of type 2 diabetes and in the protection against cardiovascular complications in (diabetic) patients with abdominal obesity. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | French |
| Relation: | http://titan.medhyg.ch/mh/formation/article.php3?sid=33427; urn:issn:1660-9379 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/5173 |
| Rights: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.5173 |
| قاعدة البيانات: | ORBi |
| الوصف غير متاح. |