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Maternal Streptococcus agalactiae colonization in Europe: data from the multi-center DEVANI study.

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العنوان: Maternal Streptococcus agalactiae colonization in Europe: data from the multi-center DEVANI study.
المؤلفون: Lohrmann, Florens, Efstratiou, Androulla, Sørensen, Uffe B Skov, Creti, Roberta, Decheva, Antoaneta, Křížová, Pavla, Kozáková, Jana, Rodriguez-Granger, Javier, De La Rosa Fraile, Manuel, Margarit, Immaculada, Rinaudo, Daniela, Maione, Domenico, Telford, John, Orefici, Graziella, Kilian, Mogens, Afshar, Baharak, Melin, Pierrette, Berner, Reinhard, Hufnagel, Markus, Kunze, Mirjam, DEVANI Study Group
المصدر: Infection (2024-09-08)
بيانات النشر: Springer Science and Business Media Deutschland GmbH, 2024.
سنة النشر: 2024
مصطلحات موضوعية: Streptococcus agalactiae, Early-onset disease, GBS vaccine, Group B streptococcus, Intrapartum prophylaxis, Maternal colonization, Neonatal sepsis, Vertical transmission, Microbiology (medical), Infectious Diseases, Human health sciences, Reproductive medicine (gynecology, andrology, obstetrics), Immunology & infectious disease, Pediatrics, Public health, health care sciences & services, Laboratory medicine & medical technology, Sciences de la santé humaine, Médecine de la reproduction (Gynécologie, andrologie, obstétrique), Immunologie & maladie infectieuse, Pédiatrie, Santé publique, services médicaux & soins de santé, Médecine de laboratoire & technologie médicale
الوصف: [en] INTRODUCTION: Despite national guidelines and use of intrapartum antibiotic prophylaxis (IAP), Streptococcus agalactiae (group B streptococci (GBS)) is still a leading cause of morbidity and mortality in newborns in Europe and the United States. The European DEVANI (Design of a Vaccine Against Neonatal Infections) program assessed the neonatal GBS infection burden in Europe, the clinical characteristics of colonized women and microbiological data of GBS strains in colonized women and their infants with early-onset disease (EOD).METHODS: Overall, 1083 pregnant women with a GBS-positive culture result from eight European countries were included in the study. Clinical obstetrical information was collected by a standardized questionnaire. GBS strains were characterized by serological and molecular methods.RESULTS: Among GBS carriers included in this study after testing positive for GBS by vaginal or recto-vaginal sampling, 13.4% had at least one additional obstetrical risk factor for EOD. The five most common capsular types (i.e., Ia, Ib, II, III and V) comprised ~ 93% of GBS carried. Of the colonized women, 77.8% received any IAP, and in 49.5% the IAP was considered appropriate. In our cohort, nine neonates presented with GBS early-onset disease (EOD) with significant regional heterogeneity.CONCLUSIONS: Screening methods and IAP rates need to be harmonized across Europe in order to reduce the rates of EOD. The epidemiological data from eight different European countries provides important information for the development of a successful GBS vaccine.
DEVANI
نوع الوثيقة: journal article
http://purl.org/coar/resource_type/c_6501
article
peer reviewed
اللغة: English
Relation: info:eu-repo/grantAgreement/EC/FP7/200481; https://link.springer.com/content/pdf/10.1007/s15010-024-02380-0.pdf; urn:issn:0300-8126; urn:issn:1439-0973
DOI: 10.1007/s15010-024-02380-0
URL الوصول: https://orbi.uliege.be/handle/2268/325309
Rights: open access
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
رقم الانضمام: edsorb.325309
قاعدة البيانات: ORBi
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