Academic Journal
Maternal Streptococcus agalactiae colonization in Europe: data from the multi-center DEVANI study.
| العنوان: | Maternal Streptococcus agalactiae colonization in Europe: data from the multi-center DEVANI study. |
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| المؤلفون: | Lohrmann, Florens, Efstratiou, Androulla, Sørensen, Uffe B Skov, Creti, Roberta, Decheva, Antoaneta, Křížová, Pavla, Kozáková, Jana, Rodriguez-Granger, Javier, De La Rosa Fraile, Manuel, Margarit, Immaculada, Rinaudo, Daniela, Maione, Domenico, Telford, John, Orefici, Graziella, Kilian, Mogens, Afshar, Baharak, Melin, Pierrette, Berner, Reinhard, Hufnagel, Markus, Kunze, Mirjam, DEVANI Study Group |
| المصدر: | Infection (2024-09-08) |
| بيانات النشر: | Springer Science and Business Media Deutschland GmbH, 2024. |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Streptococcus agalactiae, Early-onset disease, GBS vaccine, Group B streptococcus, Intrapartum prophylaxis, Maternal colonization, Neonatal sepsis, Vertical transmission, Microbiology (medical), Infectious Diseases, Human health sciences, Reproductive medicine (gynecology, andrology, obstetrics), Immunology & infectious disease, Pediatrics, Public health, health care sciences & services, Laboratory medicine & medical technology, Sciences de la santé humaine, Médecine de la reproduction (Gynécologie, andrologie, obstétrique), Immunologie & maladie infectieuse, Pédiatrie, Santé publique, services médicaux & soins de santé, Médecine de laboratoire & technologie médicale |
| الوصف: | [en] INTRODUCTION: Despite national guidelines and use of intrapartum antibiotic prophylaxis (IAP), Streptococcus agalactiae (group B streptococci (GBS)) is still a leading cause of morbidity and mortality in newborns in Europe and the United States. The European DEVANI (Design of a Vaccine Against Neonatal Infections) program assessed the neonatal GBS infection burden in Europe, the clinical characteristics of colonized women and microbiological data of GBS strains in colonized women and their infants with early-onset disease (EOD).METHODS: Overall, 1083 pregnant women with a GBS-positive culture result from eight European countries were included in the study. Clinical obstetrical information was collected by a standardized questionnaire. GBS strains were characterized by serological and molecular methods.RESULTS: Among GBS carriers included in this study after testing positive for GBS by vaginal or recto-vaginal sampling, 13.4% had at least one additional obstetrical risk factor for EOD. The five most common capsular types (i.e., Ia, Ib, II, III and V) comprised ~ 93% of GBS carried. Of the colonized women, 77.8% received any IAP, and in 49.5% the IAP was considered appropriate. In our cohort, nine neonates presented with GBS early-onset disease (EOD) with significant regional heterogeneity.CONCLUSIONS: Screening methods and IAP rates need to be harmonized across Europe in order to reduce the rates of EOD. The epidemiological data from eight different European countries provides important information for the development of a successful GBS vaccine. DEVANI |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | info:eu-repo/grantAgreement/EC/FP7/200481; https://link.springer.com/content/pdf/10.1007/s15010-024-02380-0.pdf; urn:issn:0300-8126; urn:issn:1439-0973 |
| DOI: | 10.1007/s15010-024-02380-0 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/325309 |
| Rights: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.325309 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1007/s15010-024-02380-0 |
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