Academic Journal
Osteomodulin downregulation is associated with osteoarthritis development.
| العنوان: | Osteomodulin downregulation is associated with osteoarthritis development. |
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| المؤلفون: | Zappia, Jérémie, Tong, Qiao, Van der Cruyssen, Renée, Cornelis, Frederique M F, Lambert, Cécile, Pinto Coelho, Tiago, Grisart, Juliane, Kague, Erika, Lories, Rik J, Muller, Marc, Elewaut, Dirk, Hammond, Chrissy L, Sanchez, CHRISTELLE, Henrotin, Yves |
| المساهمون: | CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège |
| المصدر: | Bone Research, 11 (1), 49 (2023-09-20) |
| بيانات النشر: | Springer Science and Business Media LLC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | osteoadherin, Proteoglycans, Male, Animals, Mice, Down-Regulation, Sclerosis, Zebrafish, Osteoarthritis/genetics, Physiology, Histology, Endocrinology, Diabetes and Metabolism, Human health sciences, Rheumatology, Sciences de la santé humaine, Rhumatologie |
| الوصف: | Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis (OA), and osteomodulin (OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA. Join-t-against-osteoarthritis |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | https://www.nature.com/articles/s41413-023-00286-5.pdf; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE230198; urn:issn:2095-4700; urn:issn:2095-6231 |
| DOI: | 10.1038/s41413-023-00286-5 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/306844 |
| Rights: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.306844 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1038/s41413-023-00286-5 |
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