Electronic Resource
Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
| العنوان: | Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis. |
|---|---|
| المؤلفون: | Nightingale, R, Reehorst, CM, Vukelic, N, Papadopoulos, N, Liao, Y, Guleria, S, Bell, C, Vaillant, F, Paul, S, Luk, IY, Dhillon, AS, Jenkins, LJ, Morrow, RJ, Jackling, FC, Chand, AL, Chisanga, D, Chen, Y, Williams, DS, Anderson, RL, Ellis, S, Meikle, PJ, Shi, W, Visvader, JE, Pal, B, Mariadason, JM |
| بيانات النشر: | Elsevier BV 2024-08-05 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The transcription factor EHF is highly expressed in the lactating mammary gland, but its role in mammary development and tumorigenesis is not fully understood. Utilizing a mouse model of Ehf deletion, herein, we demonstrate that loss of Ehf impairs mammary lobuloalveolar differentiation at late pregnancy, indicated by significantly reduced levels of milk genes and milk lipids, fewer differentiated alveolar cells, and an accumulation of alveolar progenitor cells. Further, deletion of Ehf increased proliferative capacity and attenuated prolactin-induced alveolar differentiation in mammary organoids. Ehf deletion also increased tumor incidence in the MMTV-PyMT mammary tumor model and increased the proliferative capacity of mammary tumor organoids, while low EHF expression was associated with higher tumor grade and poorer outcome in luminal A and basal human breast cancers. Collectively, these findings establish EHF as a non-redundant regulator of mammary alveolar differentiation and a putative suppressor of mammary tumorigenesis. |
| مصطلحات الفهرس: | Journal Article |
| URL: | |
| الاتاحة: | Open access content. Open access content CC BY-NC https://creativecommons.org/licenses/by-nc/4.0 |
| Other Numbers: | UMV oai:jupiter.its.unimelb.edu.au:11343/349119 Nightingale, R., Reehorst, C. M., Vukelic, N., Papadopoulos, N., Liao, Y., Guleria, S., Bell, C., Vaillant, F., Paul, S., Luk, I. Y., Dhillon, A. S., Jenkins, L. J., Morrow, R. J., Jackling, F. C., Chand, A. L., Chisanga, D., Chen, Y., Williams, D. S., Anderson, R. L. ,... Mariadason, J. M. (2024). Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.. Dev Cell, 59 (15), pp.1988-2004.e11. https://doi.org/10.1016/j.devcel.2024.04.022. 10.1016/j.devcel.2024.04.022 1878-1551 1534-5807 1456029144 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1456029144 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |