Electronic Resource
GATA6 identifies an immune-enriched phenotype linked to favorable outcomes in patients with pancreatic cancer undergoing upfront surgery
| العنوان: | GATA6 identifies an immune-enriched phenotype linked to favorable outcomes in patients with pancreatic cancer undergoing upfront surgery |
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| المؤلفون: | van Eijck, Casper H.J., Real, Francisco X., Malats, Núria, Vadgama, Disha, van den Bosch, Thierry P.P., Doukas, Michail, Mustafa, Dana A.M. |
| المصدر: | van Eijck , C H J , Real , F X , Malats , N , the Dutch Pancreatic Cancer Group (DPCG) , Vadgama , D , van den Bosch , T P P , Doukas , M , van Eijck , C H J & Mustafa , D A M 2024 , ' GATA6 identifies an immune-enriched phenotype linked to favorable outcomes in patients with pancreatic cancer undergoing upfront surgery ' , Cell Reports Medicine , vol. 5 , no. 5 , 101557 . |
| بيانات النشر: | 2024-05-21 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | This study underscores GATA6’s role in distinguishing classical and basal-like pancreatic ductal adenocarcinoma (PDAC) phenotypes. Retrospective studies associate GATA6 immunohistochemistry (IHC) expression with survival outcomes, warranting prospective validation. In a prospective treatment-naive cohort of patients with resected PDAC, GATA6 IHC proves a prognostic discriminator, associating high GATA6 expression with extended survival and the classical PDAC phenotype. However, GATA6’s prognostic significance is numerically lower after gemcitabine-based neoadjuvant chemoradiotherapy compared to its significance in patients treated with upfront surgery. Furthermore, GATA6 is implicated in immunomodulation, although a comprehensive investigation of its immunological role is lacking. Treatment-naive PDAC tumors with varying GATA6 expression yield distinct immunological landscapes. Tumors highly expressing GATA6 show reduced infiltration of immunosuppressive regulatory T cells and M2 macrophages but increased infiltration of immune-stimulating, antigen-presenting, and activated T cells. Our findings caution against solely relying on GATA6 for molecular subtyping in clinical trials and open avenues for exploring immune-based combination therapies. |
| مصطلحات الفهرس: | dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being, article |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| Other Numbers: | QGQ oai:pure.eur.nl:publications/20979046-0a99-4637-9ba1-e70fcfbecd19 https://pure.eur.nl/en/publications/20979046-0a99-4637-9ba1-e70fcfbecd19 https://doi.org/10.1016/j.xcrm.2024.101557 https://pure.eur.nl/ws/files/149997603/1-s2.0-S2666379124002490-main.pdf 1452810718 |
| المصدر المساهم: | ERASMUS UNIVERSITEIT ROTTERDAM From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1452810718 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |