Electronic Resource
In vitro bioassays for monitoring drinking water quality of tap water, domestic filtration and bottled water
| العنوان: | In vitro bioassays for monitoring drinking water quality of tap water, domestic filtration and bottled water |
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| المؤلفون: | Universitat Rovira i Virgili, Escher BI; Blanco J; Caixach J; Cserbik D; Farré MJ; Flores C; König M; Lee J; Nyffeler J; Planas C; Redondo-Hasselerharm PE; Rovira J; Sanchís J; Schuhmacher M; Villanueva CM |
| المصدر: | Journal Of Exposure Science And Environmental Epidemiology; 10.1038/s41370-023-00566-6; Journal Of Exposure Science And Environmental Epidemiology. 34 (1): 126-135 |
| بيانات النشر: | 2024 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Location-specific patterns of regulated and non-regulated disinfection byproducts (DBPs) were detected in tap water samples of the Barcelona Metropolitan Area. However, it remains unclear if the detected DBPs together with undetected DPBs and organic micropollutants can lead to mixture effects in drinking water.To evaluate the neurotoxicity, oxidative stress response and cytotoxicity of 42 tap water samples, 6 treated with activated carbon filters, 5 with reverse osmosis and 9 bottled waters. To compare the measured effects of the extracts with the mixture effects predicted from the detected concentrations and the relative effect potencies of the detected DBPs using the mixture model of concentration addition.Mixtures of organic chemicals in water samples were enriched by solid phase extraction and tested for cytotoxicity and neurite outgrowth inhibition in the neuronal cell line SH-SY5Y and for cytotoxicity and oxidative stress response in the AREc32 assay.Unenriched water did not trigger neurotoxicity or cytotoxicity. After up to 500-fold enrichment, few extracts showed cytotoxicity. Disinfected water showed low neurotoxicity at 20- to 300-fold enrichment and oxidative stress response at 8- to 140-fold enrichment. Non-regulated non-volatile DBPs, particularly (brominated) haloacetonitriles dominated the predicted mixture effects of the detected chemicals and predicted effects agreed with the measured effects. By hierarchical clustering we identified strong geographical patterns in the types of DPBs and their association with effects. Activated carbon filters did not show a consistent reduction of effects but domestic reverse osmosis filters decreased the effect to that of bottled water.Bioassays are an important complement to chemical analysis of disinfection by-produ |
| مصطلحات الفهرس: | Environmental Sciences,Epidemiology,Pollution,Public Health, Environmental and Occupational Health,Public, Environmental & Occupational Health,Toxicology, Water quality, Oxidative stress, Neurotoxicity, Disinfection by-products, Bioassay, toxicity, oxidative stress-response, oxidative stress, neurotoxicity, micropollutants, mammalian-cell cytotoxicity, health, genotoxicity, disinfection by-products, dibromoacetonitrile, chemicals, bioassay, bioanalytical assessment, Toxicology, Saúde coletiva, Public, environmental & occupational health, Public health, environmental and occupational health, Pollution, Medicina ii, Interdisciplinar, Farmacia, Epidemiology, Environmental sciences, Enfermagem, Ciências biológicas ii, Ciências ambientais, Journal Publications |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| Other Numbers: | RIV oai:urv.cat:imarina:9321830 1443596449 |
| المصدر المساهم: | UNIVERSITAT ROVIRA I VIRGILI BIBLIOTECA From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1443596449 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |