Electronic Resource
Impaired mRNA splicing and proteostasis in preadipocytes in obesity related metabolic disease
| العنوان: | Impaired mRNA splicing and proteostasis in preadipocytes in obesity related metabolic disease |
|---|---|
| المؤلفون: | Universitat Rovira i Virgili, Sánchez-Ceinos J; Guzmán-Ruiz R; Rangel-Zúñiga OA; López-Alcalá J; Moreno-Caño E; Del Río-Moreno M; Romero-Cabrera JL; Pérez-Martínez P; Maymo-Masip E; Vendrell J; Fernández-Veledo S; Fernández-Real JM; Laurencikiene J; Rydén M; Membrives A; Luque RM; López-Miranda J; Malagón MM |
| المصدر: | Elife; 10.7554/eLife.65996; Elife. 10 |
| بيانات النشر: | 2021 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Preadipocytes are crucial for healthy adipose tissue expansion. Preadipocyte differentiation is altered in obese individuals, which has been proposed to contribute to obesity-associated metabolic disturbances. Here, we aimed at identifying the pathogenic processes underlying impaired adipocyte differentiation in obese individuals with insulin resistance (IR)/type 2 diabetes (T2D). We report that down-regulation of a key member of the major spliceosome, PRFP8/PRP8, as observed in IR/T2D preadipocytes from subcutaneous (SC) fat, prevented adipogenesis by altering both the expression and splicing patterns of adipogenic transcription factors and lipid droplet-related proteins, while adipocyte differentiation was restored upon recovery of PRFP8/PRP8 normal levels. Adipocyte differentiation was also compromised under conditions of endoplasmic reticulum (ER)-associated protein degradation (ERAD) hyperactivation, as occurs in SC and omental (OM) preadipocytes in IR/T2D obesity. Thus, targeting mRNA splicing and ER proteostasis in preadipocytes could improve adipose tissue function and thus contribute to metabolic health in obese individuals. |
| مصطلحات الفهرس: | Biochemistry, Genetics and Molecular Biology (Miscellaneous),Biology,Immunology and Microbiology (Miscellaneous),Medicine (Miscellaneous),Neuroscience (Miscellaneous), Preadipocytes, Human adipose-tissue, upr, tool, stress, rna splicing, obesity-related metabolic diseases, insulin-resistance, human adipocytes, human, homeostasis, fat, erad, er-proteostasis, differentiation, cells, adipogenesis, Saúde coletiva, Química, Nutrição, Neuroscience (miscellaneous), Neuroscience (all), Medicine (miscellaneous), Medicina veterinaria, Medicina ii, Medicina i, Interdisciplinar, Immunology and microbiology (miscellaneous), Immunology and microbiology (all), Geografía, Geociências, General neuroscience, General medicine, General immunology and microbiology, General biochemistry,genetics and molecular biology, Farmacia, Educação física, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências agrárias i, Biotecnología, Biology, Biodiversidade, Biochemistry, genetics and molecular biology (miscellaneous), Biochemistry, genetics and molecular biology (all), Astronomia / física, Journal Publications |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| Other Numbers: | RIV oai:urv.cat:imarina:9230389 1443579482 |
| المصدر المساهم: | UNIVERSITAT ROVIRA I VIRGILI BIBLIOTECA From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1443579482 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |