Electronic Resource
Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1
| العنوان: | Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1 |
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| المؤلفون: | Universitat Rovira i Virgili, Masana L, Zamora A, Plana N, Comas-Cufí M, Garcia-Gil M, Martí-Lluch R, Ponjoan A, Alves-Cabratosa L, Elosua R, Marrugat J, Dégano IR, Ramos R |
| المصدر: | Journal Of Clinical Medicine; 10.3390/jcm8071080; Journal Of Clinical Medicine. 8 (7): |
| بيانات النشر: | 2019 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with FH-phenotype (FH-P) and to compare it with that of normal low-density lipoprotein cholesterol (LDL-C) patients. We performed a retrospective cohort study using the Database of the Catalan primary care system, including ≥18-year-old patients with an LDL-C measurement. From 1,589,264 patients available before 2009, 12,823 fulfilled FH-P criteria and 514,176 patients were normolipidemic (LDL-C < 115 mg/dL). In primary prevention, patients with FH-P had incidences of ASCVD and coronary heart disease (CHD) of 14.9/1000 and 5.8/1000 person-years, respectively, compared to 7.1/1000 and 2.1/1000 person-years in the normolipidemic group. FH-P showed hazard ratio (HR) of 7.1 and 16.7 for ASCVD and CHD, respectively, in patients younger than 35 years. In secondary prevention, patients with FH-P had incidences of ASCVD and CHD of 89.7/1000 and 34.5/1000 person-years, respectively, compared to 90.9/1000 and 28.2/1000 person-years in the normolipidemic group (HR in patients younger than 35 years: 2.4 and 6.0). In the statin era, FH-P remains associated with high cardiovascular risk, compared with the normolipidemic population. This excess of risk is markedly high in young individuals. |
| مصطلحات الفهرس: | Medicine (Miscellaneous),Medicine, General & Internal, Risk assessment, Real-world data, Primary-care, Prevention, Population-prevalence, Management, Incidence, Familial hypercholesterolemia, Diagnosis, Cardiovascular diseases, Atherosclerosis, Medicine, general & internal, Medicine (miscellaneous), Medicine (all), Journal Publications |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| Other Numbers: | RIV oai:urv.cat:imarina:5873595 1443572962 |
| المصدر المساهم: | UNIVERSITAT ROVIRA I VIRGILI BIBLIOTECA From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1443572962 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |