Electronic Resource
Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)
| العنوان: | Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS) |
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| المؤلفون: | Weil, Alexander G; https://orcid.org/0000-0003-4162-6096, Dimentberg, Evan; https://orcid.org/0009-0007-6315-1737, Lewis, Evan, Ibrahim, George M; https://orcid.org/0000-0001-9068-8184, Kola, Olivia, Tseng, Chi-Hong, Chen, Jia-Shu; https://orcid.org/0000-0002-4533-9476, Lin, Kao-Min, Cai, Li-Xin, Liu, Qing-Zhu, Lin, Jiu-Luan, Zhou, Wen-Jing; https://orcid.org/0000-0002-7272-6236, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia; https://orcid.org/0000-0002-7931-2327, Zentner, Josef, Wang, Anthony C, Dorfer, Christian; https://orcid.org/0000-0002-1843-7732, Feucht, Martha; https://orcid.org/0000-0001-7691-8158, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connolly, Mary, Krayenbühl, Niklaus; https://orcid.org/0000-0002-4973-7527, et al |
| المصدر: | Weil, Alexander G; Dimentberg, Evan; Lewis, Evan; Ibrahim, George M; Kola, Olivia; Tseng, Chi-Hong; Chen, Jia-Shu; Lin, Kao-Min; Cai, Li-Xin; Liu, Qing-Zhu; Lin, Jiu-Luan; Zhou, Wen-Jing; Mathern, Gary W; Smyth, Matthew D; O'Neill, Brent R; Dudley, Roy; Ragheb, John; Bhatia, Sanjiv; Delev, Daniel; Ramantani, Georgia; Zentner, Josef; Wang, Anthony C; Dorfer, Christian; Feucht, Martha; Czech, Thomas; Bollo, Robert J; Issabekov, Galymzhan; Zhu, Hongwei; Connolly, Mary; Krayenbühl, Niklaus; et al (2024). Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS). Epilepsia, 65(1):46-56. |
| بيانات النشر: | Wiley-Blackwell Publishing, Inc. 2024-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | OBJECTIVES Although hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in the pediatric population, there is a large variability in seizure outcomes at the group level. A recently developed HOPS score provides individualized estimation of likelihood of seizure freedom to complement clinical judgement. The objective of this study was to develop a freely accessible online calculator that accurately predicts the probability of seizure freedom for any patient at 1-, 2-, and 5-years post-hemispherectomy. METHODS Retrospective data of all pediatric patients with DRE and seizure outcome data from the original Hemispherectomy Outcome Prediction Scale (HOPS) study were included. The primary outcome of interest was time-to-seizure recurrence. A multivariate Cox proportional-hazards regression model was developed to predict the likelihood of post-hemispheric surgery seizure freedom at three time points (1-, 2- and 5- years) based on a combination of variables identified by clinical judgment and inferential statistics predictive of the primary outcome. The final model from this study was encoded in a publicly accessible online calculator on the International Network for Epilepsy Surgery and Treatment (iNEST) website (https://hops-calculator.com/). RESULTS The selected variables for inclusion in the final model included the five original HOPS variables (age at seizure onset, etiologic substrate, seizure semiology, prior non-hemispheric resective surgery, and contralateral fluorodeoxyglucose-positron emission tomography [FDG-PET] hypometabolism) and three additional variables (age at surgery, history of infantile spasms, and magnetic resonance imaging [MRI] lesion). Predictors of shorter time-to-seizure recurrence included younger age at seizure onset, prior resective surgery, generalized seizure semiology, FDG-PET hypometabolism contralateral to the side of surgery, contralateral MRI lesion, non-lesional MRI, non-stroke etiologies, an |
| مصطلحات الفهرس: | Medical Clinic, 610 Medicine & health, Journal Article, PeerReviewed, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | 10.1111/epi.17689 |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf info:doi/10.5167/uzh-256059 English English |
| Other Numbers: | CHUZH oai:www.zora.uzh.ch:256059 https://www.zora.uzh.ch/id/eprint/256059/1/ZORA256059.pdf info:doi/10.5167/uzh-256059 info:doi/10.1111/epi.17689 info:pmid/37347512 urn:issn:0013-9580 1443057933 |
| المصدر المساهم: | HAUPTBIBLIOTHEK UNIV OF ZURICH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1443057933 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |