Electronic Resource
The spinal cord injury-induced immune deficiency syndrome: results of the SCIentinel study
| العنوان: | The spinal cord injury-induced immune deficiency syndrome: results of the SCIentinel study |
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| المؤلفون: | Kopp, Marcel A; https://orcid.org/0000-0001-6832-9599, Meisel, Christian; https://orcid.org/0000-0003-0222-991X, Liebscher, Thomas; https://orcid.org/0000-0002-6025-6564, Watzlawick, Ralf, Cinelli, Paolo; https://orcid.org/0000-0002-0163-9055, Schweizerhof, Oliver, Blex, Christian, Lübstorf, Tom, Prilipp, Erik, Niedeggen, Andreas, Druschel, Claudia, Schaser, Klaus-Dieter, Wanner, Guido A, Curt, Armin, Lindemann, Gertraut, Nugeva, Natalia, Fehlings, Michael G; https://orcid.org/0000-0002-5722-6364, Vajkoczy, Peter, Cabraja, Mario, Dengler, Julius, Ertel, Wolfgang, Ekkernkamp, Axel, Rehahn, Kerstin, Martus, Peter, Volk, Hans-Dieter, Unterwalder, Nadine, Kölsch, Uwe, Brommer, Benedikt, Hellmann, Rick C, Baumgartner, Elias, et al |
| المصدر: | Kopp, Marcel A; Meisel, Christian; Liebscher, Thomas; Watzlawick, Ralf; Cinelli, Paolo; Schweizerhof, Oliver; Blex, Christian; Lübstorf, Tom; Prilipp, Erik; Niedeggen, Andreas; Druschel, Claudia; Schaser, Klaus-Dieter; Wanner, Guido A; Curt, Armin; Lindemann, Gertraut; Nugeva, Natalia; Fehlings, Michael G; Vajkoczy, Peter; Cabraja, Mario; Dengler, Julius; Ertel, Wolfgang; Ekkernkamp, Axel; Rehahn, Kerstin; Martus, Peter; Volk, Hans-Dieter; Unterwalder, Nadine; Kölsch, Uwe; Brommer, Benedikt; Hellmann, Rick C; Baumgartner, Elias; et al (2023). The spinal cord injury-induced immune deficiency syndrome: results of the SCIentinel study. Brain: a journal of neurology, 146(8):3500-3512. |
| بيانات النشر: | Oxford University Press 2023-08-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Infections are prevalent after spinal cord injury (SCI), constitute the main cause of death and are a rehabilitation confounder associated with impaired recovery. We hypothesize that SCI causes an acquired lesion-dependent (neurogenic) immune suppression as an underlying mechanism to facilitate infections. The international prospective multicentre cohort study (SCIentinel; protocol registration DRKS00000122; n = 111 patients) was designed to distinguish neurogenic from general trauma-related effects on the immune system. Therefore, SCI patient groups differing by neurological level, i.e. high SCI [thoracic (Th)4 or higher]; low SCI (Th5 or lower) and severity (complete SCI; incomplete SCI), were compared with a reference group of vertebral fracture (VF) patients without SCI. The primary outcome was quantitative monocytic Human Leukocyte Antigen-DR expression (mHLA-DR, synonym MHC II), a validated marker for immune suppression in critically ill patients associated with infection susceptibility. mHLA-DR was assessed from Day 1 to 10 weeks after injury by applying standardized flow cytometry procedures. Secondary outcomes were leucocyte subpopulation counts, serum immunoglobulin levels and clinically defined infections. Linear mixed models with multiple imputation were applied to evaluate group differences of logarithmic-transformed parameters. Mean quantitative mHLA-DR [ln (antibodies/cell)] levels at the primary end point 84 h after injury indicated an immune suppressive state below the normative values of 9.62 in all groups, which further differed in its dimension by neurological level: high SCI [8.95 (98.3% confidence interval, CI: 8.63; 9.26), n = 41], low SCI [9.05 (98.3% CI: 8.73; 9.36), n = 29], and VF without SCI [9.25 (98.3% CI: 8.97; 9.53), n = 41, P = 0.003]. Post hoc analysis accounting for SCI severity revealed the strongest mHLA-DR decrease [8.79 (95% CI: 8.50; 9.08)] in the complete, high SCI group, further demonstrating delayed mHLA-DR recovery [9.08 ( |
| مصطلحات الفهرس: | Department of Trauma Surgery, Balgrist University Hospital, Swiss Spinal Cord Injury Center, 610 Medicine & health, Journal Article, PeerReviewed, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | 10.1093/brain/awad092 |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf info:doi/10.5167/uzh-234557 English English |
| Other Numbers: | CHUZH oai:www.zora.uzh.ch:234557 https://www.zora.uzh.ch/id/eprint/234557/1/2023_Kopp_Brain_The_spinal_cord_injury_induced_immune_deficiency.pdf info:doi/10.5167/uzh-234557 info:doi/10.1093/brain/awad092 info:pmid/37370200 urn:issn:0006-8950 1443052873 |
| المصدر المساهم: | HAUPTBIBLIOTHEK UNIV OF ZURICH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1443052873 |
| قاعدة البيانات: | OAIster |
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