Electronic Resource
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
| العنوان: | Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization |
|---|---|
| المؤلفون: | Friedrich, Nikolas; https://orcid.org/0000-0003-0694-657X, Stiegeler, Emanuel, Glögl, Matthias, Lemmin, Thomas, Hansen, Simon, Kadelka, Claus; https://orcid.org/0000-0002-5712-8529, Wu, Yufan, Ernst, Patrick; https://orcid.org/0000-0001-6037-1856, Maliqi, Liridona, Foulkes, Caio, Morin, Mylène, Eroglu, Mustafa, Liechti, Thomas, Ivan, Branislav, Reinberg, Thomas, Schaefer, Jonas V, Karakus, Umut, Ursprung, Stephan; https://orcid.org/0000-0003-2476-178X, Mann, Axel, Rusert, Peter, Kouyos, Roger D; https://orcid.org/0000-0002-9220-8348, Robinson, John A; https://orcid.org/0000-0001-7857-8556, Günthard, Huldrych F; https://orcid.org/0000-0002-1142-6723, Plückthun, Andreas; https://orcid.org/0000-0003-4191-5306, Trkola, Alexandra; https://orcid.org/0000-0003-1013-876X |
| المصدر: | Friedrich, Nikolas; Stiegeler, Emanuel; Glögl, Matthias; Lemmin, Thomas; Hansen, Simon; Kadelka, Claus; Wu, Yufan; Ernst, Patrick; Maliqi, Liridona; Foulkes, Caio; Morin, Mylène; Eroglu, Mustafa; Liechti, Thomas; Ivan, Branislav; Reinberg, Thomas; Schaefer, Jonas V; Karakus, Umut; Ursprung, Stephan; Mann, Axel; Rusert, Peter; Kouyos, Roger D; Robinson, John A; Günthard, Huldrych F; Plückthun, Andreas; Trkola, Alexandra (2021). Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nature Communications, 12:6705. |
| بيانات النشر: | Nature Publishing Group 2021-11-18 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The V3 loop of the HIV-1 envelope (Env) protein elicits a vigorous, but largely non-neutralizing antibody response directed to the V3-crown, whereas rare broadly neutralizing antibodies (bnAbs) target the V3-base. Challenging this view, we present V3-crown directed broadly neutralizing Designed Ankyrin Repeat Proteins (bnDs) matching the breadth of V3-base bnAbs. While most bnAbs target prefusion Env, V3-crown bnDs bind open Env conformations triggered by CD4 engagement. BnDs achieve breadth by focusing on highly conserved residues that are accessible in two distinct V3 conformations, one of which resembles CCR5-bound V3. We further show that these V3-crown conformations can, in principle, be attacked by antibodies. Supporting this conclusion, analysis of antibody binding activity in the Swiss 4.5 K HIV-1 cohort (n = 4,281) revealed a co-evolution of V3-crown reactivities and neutralization breadth. Our results indicate a role of V3-crown responses and its conformational preferences in bnAb development to be considered in preventive and therapeutic approaches. |
| مصطلحات الفهرس: | Department of Biochemistry, Clinic for Infectious Diseases, Institute of Medical Virology, 570 Life sciences; biology, 610 Medicine & health, Journal Article, PeerReviewed, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | 10.1038/s41467-021-27075-0 |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess Creative Commons: Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf info:doi/10.5167/uzh-210334 English |
| Other Numbers: | CHUZH oai:www.zora.uzh.ch:210334 https://www.zora.uzh.ch/id/eprint/210334/1/Friedrich_et_al._2021.pdf info:doi/10.5167/uzh-210334 info:doi/10.1038/s41467-021-27075-0 info:pmid/34795280 urn:issn:2041-1723 1443041281 |
| المصدر المساهم: | HAUPTBIBLIOTHEK UNIV OF ZURICH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1443041281 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |