Electronic Resource
Acidic Urine pH and Clinical Outcome of Lower Urinary Tract Infection in Kidney Transplant Recipients Treated with Ciprofloxacin and Fosfomycin
| العنوان: | Acidic Urine pH and Clinical Outcome of Lower Urinary Tract Infection in Kidney Transplant Recipients Treated with Ciprofloxacin and Fosfomycin |
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| المؤلفون: | Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad (España), Junta de Andalucía, European Commission, Universidad de Sevilla, Red Española de Investigación en Patología Infecciosa, Herrera-Espejo, Soraya [0000-0001-8019-0905], Pachón, Jerónimo [0000-0002-8166-5308], Pachón-Ibáñez, M. E. [0000-0001-7969-8162], Cordero, Elisa [0000-0001-7766-7266], Herrera-Espejo, Soraya, Fontserè, Sara, Infante, Carmen, Suárez-Benjumea, Alejandro, Carretero-Ledesma, Marta, Suñer, Marta, González-Corvillo, Carmen, Bernal, Gabriel, Martín-Gutiérrez, Guillermo, Pérez-Cáceres, Juan Antonio, Pachón, Jerónimo, Pachón-Ibáñez, M. E., Cordero, Elisa |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute 2024-01-22 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Different factors, including antimicrobial resistance, may diminish the effectiveness of antibiotic therapy, challenging the management of post-transplant urinary tract infection (UTI). The association of acidic urine pH with microbiological and clinical outcomes was evaluated after fosfomycin or ciprofloxacin therapy in 184 kidney transplant recipients (KTRs) with UTI episodes by Escherichia coli (N = 115) and Klebsiella pneumoniae (N = 69). Initial urine pH, antimicrobial therapy, and clinical and microbiological outcomes, and one- and six-month follow-up were assessed. Fosfomycin was prescribed in 88 (76.5%) E. coli and 46 (66.7%) K. pneumoniae UTI episodes in the total cohort. When the urine pH ≤ 6, fosfomycin was prescribed in 60 (52.2%) E. coli and 29 (42.0%) K. pneumoniae. Initial urine pH ≤ 6 in E. coli UTI was associated with symptomatic episodes (8/60 vs. 0/55, p = 0.04) at one-month follow-up, with a similar trend in those patients receiving fosfomycin (7/47 vs. 0/41, p = 0.09). Acidic urine pH was not associated with microbiological or clinical cure in K. pneumoniae UTI. At pH 5, the ciprofloxacin MIC90 increased from 8 to >8 mg/L in E. coli and from 4 to >8 mg/L in K. pneumoniae. At pH 5, the fosfomycin MIC90 decreased from 8 to 4 mg/L in E. coli and from 512 to 128 mg/L in K. pneumoniae. Acidic urine is not associated with the microbiological efficacy of fosfomycin and ciprofloxacin in KTRs with UTI, but it is associated with symptomatic UTI episodes at one-month follow-up in E. coli episodes. |
| مصطلحات الفهرس: | Urine pH, Escherichia coli, Klebsiella pneumoniae, Ciprofloxacin, Fosfomycin, Kidney transplant recipients, Urinary tract infections, artículo |
| URL: | Publisher's version The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/antibiotics13020116 Sí |
| الاتاحة: | Open access content. Open access content https://creativecommons.org/licenses/by/4.0 openAccess |
| ملاحظة: | English |
| Other Numbers: | CTK oai:digital.csic.es:10261/359835 Antibiotics 13(2): 116 (2024) 10.3390/antibiotics13020116 2079-6382 38391502 2-s2.0-85187226332 1442728082 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1442728082 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |