Electronic Resource
Modifying the Catalytic Activity of Lipopeptide Assemblies with Nucleobases
| العنوان: | Modifying the Catalytic Activity of Lipopeptide Assemblies with Nucleobases |
|---|---|
| المؤلفون: | Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, 0000-0003-2853-6221, 0000-0002-0342-4701, 0000-0002-6083-7756, 0009-0007-3086-5549, #NODATA#, 0000-0002-3075-5741, 0000-0002-0928-8317, Vela-Gallego, Sonia, Lewandowski, Bartosz, Möhler, Jasper, Puente, Alonso, Gil-Cantero, David, Wennemers, Helma, de la Escosura, Andrés |
| بيانات النشر: | 2024-01-02 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Biohybrid catalysts that operate in aqueous media are intriguing for systems chemistry. In this paper, we investigate whether control over the self-assembly of biohybrid catalysts can tune their properties. As a model, we use the catalytic activity of functional hybrid molecules consisting of a catalytic H-dPro-Pro-Glu tripeptide, derivatized with fatty acid and nucleobase moieties. This combination of simple biological components merged the catalytic properties of the peptide with the self-assembly of the lipid, and the structural ordering of the nucleobases. The biomolecule hybrids self-assemble in aqueous media into fibrillar assemblies and catalyze the reaction between butanal and nitrostyrene. The interactions between the nucleobases enhanced the order of the supramolecular structures and affected their catalytic activity and stereoselectivity. The results point to the significant control and ordering that nucleobases can provide in the self-assembly of biologically inspired supramolecular catalysts. |
| مصطلحات الفهرس: | assemblies; catalysis; lipopeptides; nucleobases; supramolecular, Journal Article |
| URL: | Chemistry (Weinheim an der Bergstrasse, Germany) Publisher's version Sí |
| الاتاحة: | Open access content. Open access content openAccess |
| ملاحظة: | English |
| Other Numbers: | CTK oai:digital.csic.es:10261/358935 Chemistry - a European Journal 09476539 10.1002/chem.202303395 37877614 2-s2.0-85175992536 1442727255 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1442727255 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |