Electronic Resource
Biomimetic triumvirate nanogel complexes via peptide-polysaccharide-polyphenol self-assembly.
| العنوان: | Biomimetic triumvirate nanogel complexes via peptide-polysaccharide-polyphenol self-assembly. |
|---|---|
| المؤلفون: | Tai, M-R, Ji, H-W, Chen, J-P, Liu, X-F, Song, B-B, Zhong, S-Y, Rifai, A, Nisbet, DR, Barrow, CJ, Williams, RJ, Li, R |
| بيانات النشر: | Elsevier 2023-08-08 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Self-assembled peptide and polysaccharide nanogels are excellent candidates for bioactive delivery vectors. However, there are still significant challenges in the application of nanogels as delivery tools for bioactive elements. This study aims to deliver, and control the release of a hydrophobic bioactive flavonoid hesperidin. Using the self-assembling peptide (SAP) Fmoc-FRGDF, extracellular matrix mimicking nanofibrils were fabricated, which were decorated and bolstered with immunomodulatory polysaccharide strands of fucoidan and infused with hesperidin. The mechanical properties, secondary structure, and microscopic morphologies of the composite hydrogels were characterized using rheometer, FTIR, XRD, and TEM, etc. The encapsulation efficiency (EE) and release behavior of hesperidin were determined. Coassembly of the SAP with fucoidan improved the mechanical properties (from 9.54 Pa of Fmoc-FRGDF hydrogel to 7735 Pa of coassembly hydrogel at 6 mg/mL fucoidan concentration), formed thicker nanofibril bundles at 4 and 6 mg/mL fucoidan concentration, improved the EE of hesperidin from 72.86 % of Fmoc-FRGDF hydrogel to over 90 % of coassembly hydrogels, and showed effectively controlled release of hesperidin in vitro. Intriguingly, the first order kinetic model predicted an enhanced hydrogel retention and release of hesperidin. This study revealed a new approach for bioengineered nanogels that could be used to stabilize and release hydrophobic payloads. |
| مصطلحات الفهرس: | 0601 Biochemistry and Cell Biology, Journal Article |
| URL: | Int J Biol Macromol 10.1016/j.ijbiomac.2023.126232 |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/closedAccess |
| Other Numbers: | LT1 oai:opus.lib.uts.edu.au:10453/177523 Int J Biol Macromol, 2023, 251, pp. 126232 0141-8130 1879-0003 1439678486 |
| المصدر المساهم: | UNIV OF TECH, SYDNEY From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1439678486 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |