Electronic Resource
Mitophagy curtails cytosolic mtDNAdependent activation of cGAS/STING inflammation during aging
| العنوان: | Mitophagy curtails cytosolic mtDNAdependent activation of cGAS/STING inflammation during aging |
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| المؤلفون: | Swiss National Science Foundation, Ministerio de Ciencia e Innovación (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Jiménez-Loygorri, Juan Ignacio [0000-0002-3065-9952], Villarejo-Zori, Beatriz [0000-0002-5502-4793], Viedma-Poyatos, Álvaro [0000-0003-4920-6328], Zapata-Muñoz, Juan [0000-0003-4747-920X], Benítez-Fernández, Rocío [0000-0003-3535-4370], Frutos-Lisón, M.D. [0000-0002-7899-5744], Tomás-Barberán, Francisco Abraham [0000-0002-0790-1739], Espín, Juan Carlos [0000-0002-1068-8692], Area-Gomez, Estela [0000-0002-0962-1570], Gómez-Durán, Aurora [0000-0002-5895-6860], Boya, Patricia [0000-0003-3045-951X], Jiménez-Loygorri, Juan Ignacio, Villarejo-Zori, Beatriz, Viedma-Poyatos, Álvaro, Zapata-Muñoz, Juan, Benítez-Fernández, Rocío, Frutos-Lisón, M.D., Tomás Barberán, Francisco, Espín de Gea, Juan Carlos, Area-Gomez, Estela, Gómez-Durán, Aurora, Boya, Patricia |
| بيانات النشر: | Springer Nature 2024-01-27 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Macroautophagy decreases with age, and this change is considered a hallmark of the aging process. It remains unknown whether mitophagy, the essential selective autophagic degradation of mitochondria, also decreases with age. In our analysis of mitophagy in multiple organs in the mito-QC reporter mouse, mitophagy is either increased or unchanged in old versus young mice. Transcriptomic analysis shows marked upregulation of the type I interferon response in the retina of old mice, which correlates with increased levels of cytosolic mtDNA and activation of the cGAS/STING pathway. Crucially, these same alterations are replicated in primary human fibroblasts from elderly donors. In old mice, pharmacological induction of mitophagy with urolithin A attenuates cGAS/STING activation and ameliorates deterioration of neurological function. These findings point to mitophagy induction as a strategy to decrease age-associated inflammation and increase healthspan. |
| مصطلحات الفهرس: | artículo |
| URL: | Publisher's version Sí info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103914RB-I00/ES/ESTRATEGIAS FRONTERA MEDIANTE TRASPLANTES FECALES: METABOTIPOS DE POLIFENOLES ASOCIADOS A LA MICROBIOTA INTESTINAL, RIESGO CARDIOMETABOLICO Y DETERIORO COGNITIVO info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114709RA-I00/ES/ FACTORES FENOTIPICOS QUE MODULAN LA PENETRANCIA DE LA ENFERMEDAD MITOCONDRIAL. UN ENFOQUE INTEGROMICO. |
| الاتاحة: | Open access content. Open access content https://creativecommons.org/licenses/by/4.0 openAccess |
| ملاحظة: | English |
| Other Numbers: | CTK oai:digital.csic.es:10261/348222 Nature Communications 15: 830 (2024) 10.1038/s41467-024-45044-1 2041-1723 1431962978 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1431962978 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |