Electronic Resource
Incorporation of Tb and Gd improves the diagnostic functionality of magnetotactic bacteria
| العنوان: | Incorporation of Tb and Gd improves the diagnostic functionality of magnetotactic bacteria |
|---|---|
| المؤلفون: | Física Aplicada, Fisika Aplikatua, Gandarias Albaina, Lucia, Jefremovas, Elizabeth M., Gandia Aguado, David, Marcano Prieto, Lourdes, Martínez Martínez, Virginia, Ramos Cabrer, Pedro, Chevrier, Daniel M., Valencia, Sergio, Fernández Barquín, Luis, Fernández Gubieda Ruiz, María Luisa, Alonso, Javier, García Prieto, Ana, Muela Blázquez, Alicia |
| بيانات النشر: | Elsevier 2023-05-24 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Magnetotactic bacteria are envisaged as potential theranostic agents. Their internal magnetic compass, chemical environment specificity and natural motility enable these microorganisms to behave as nanorobots, as they can be tracked and guided towards specific regions in the body and activated to generate a therapeutic response. Here we provide additional diagnostic functionalities to magnetotactic bacteria Magnetospirillum gryphiswaldense MSR-1 while retaining their intrinsic capabilities. These additional functionalities are achieved by incorporating Tb or Gd in the bacteria by culturing them in Tb/Gd supplemented media. The incorporation of Tb provides luminescence properties, enabling potential applications of bacteria as biomarkers. The incorporation of Gd turns bacteria into dual contrast agents for magnetic resonance imaging, since Gd adds T1 contrast to the existing T2 contrast of unmodified bacteria. Given their potential clinical applications, the diagnostic ability of the modified MSR-1 has been successfully tested in vitro in two cell models, confirming their suitability as fluorescent markers (Tb-MSR-1) and dual contrast agents for MRI (Gd-MSR-1). |
| مصطلحات الفهرس: | magnetotactic bacteria, theranostic agents, luminescent markers, magnetic resonance imaging, X-ray absorption spectroscopy, magnetic hyperthermia, info:eu-repo/semantics/article |
| URL: | 2590-0064 info:eu-repo/grantAgreement/MICIN/RED 2018-102626-T |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | This work has been funded by the Spanish Government (grants PID2020-115704RB-C31, PID2020-114347RB-C32, PID2020-115704RB-C33 and RED 2018–102626–T (HIPERNANO) funded by MCIN/AEI/10.13039/501100011033) and by the Basque Government (projects IT1479-22 and IT1639-22). LG acknowledges the Spanish Government for her PhD/Postdoctoral fellowship (PRE2018-083255 funded by MCIN/AEI/10.13039/501100011033 and by European Union Next GenerationEU/PRTR). EMJ acknowledges the Beca Concepción Arenal (Gobierno de Cantabria – Grant n. 406333) and Alexander von Humboldt Postdoctoral Fellowship. LM acknowledges the BBVA Foundation for the Leonardo Fellowships for Researchers and Cultural Creators 2022. English |
| Other Numbers: | ESUPV oai:addi.ehu.eus:10810/65967 1430741777 |
| المصدر المساهم: | REPOSITORIO DE LA UNIVERSIDAD DEL PAIS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1430741777 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |