Electronic Resource
On the Use of Orthoformates as an Efficient Approach to Enhance the Enzymatic Enantioselective Synthesis of (S)-Ibuprofen
| العنوان: | On the Use of Orthoformates as an Efficient Approach to Enhance the Enzymatic Enantioselective Synthesis of (S)-Ibuprofen |
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| المؤلفون: | Sánchez Montero, José, Alcántara León, Andrés Rafael, Khiari, Oussama, Bouzemi, Nassima |
| بيانات النشر: | MDPI 2024-01-11T12:35:37Z 2024-01-11T12:35:37Z 2023-01-22 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | In this paper, we describe the effectiveness of the combination between an organic solvent system mixture with orthoformates with different chain sizes from one to four carbon atoms. These orthoesters have been used as a “water trapper/alcohol releaser molecule” to reach a notable improvement in enantioselectivity and enantiomeric excess of our target compound, (S)-2-(4-isobutylphenyl)propanoic acid (ibuprofen eutomer), during the enzymatic kinetic resolution of rac-ibuprofen using immobilized lipase B of Candida antarctica as a biocatalyst. At the same time, one of the great problems of biocatalysis in organic media has been solved by eliminating excess water in the medium that allows the reversibility of the reaction. Following the optimization of the reaction conditions, an increase in enantiomeric excess and enantioselectivity was reached by using these acyl donors in the presence of a cosolvent. Spanish Ministry of Science and Innovation Depto. de Química en Ciencias Farmacéuticas Fac. de Farmacia TRUE pub |
| مصطلحات الفهرس: | 6, 612.015, kinetic resolution, ibuprofen, eutomer, lipase, irreversible esterification, orthoformates, water trapping, cosolvents, Ciencias, Ciencias Biomédicas, 23 Química, 24 Ciencias de la Vida, journal article, VoR |
| URL: | info:eu-repo/grantAgreement/PID2019-105337RB-C22 |
| الاتاحة: | Open access content. Open access content Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 open access |
| ملاحظة: | application/pdf 2073-4344 English |
| Other Numbers: | ESRCM oai:docta.ucm.es:20.500.14352/92528 Khiari, O.; Bouzemi, N.; Sánchez-Montero, J.M.; Alcántara, A.R. On the Use of Orthoformates as an Efficient Approach to Enhance the Enzymatic Enantioselective Synthesis of (S)-Ibuprofen. Catalysts 2023, 13, 251. https://doi.org/10.3390/catal13020251 2073-4344 1429626008 |
| المصدر المساهم: | REPOSITORIO E-PRINTS UNIVERSIDAD COMPLU From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1429626008 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |