Electronic Resource
Stereotactic body radiotherapy for early-stage non-small cell lung cancer: a multicentre study by the Oncologic Group for the Study of Lung Cancer (Spanish Radiation Oncology Society)
| العنوان: | Stereotactic body radiotherapy for early-stage non-small cell lung cancer: a multicentre study by the Oncologic Group for the Study of Lung Cancer (Spanish Radiation Oncology Society) |
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| المؤلفون: | Samper Ots, P. Mª et al., Ferrer Albiach, C., Alcántara Carrió, María Del Pino |
| بيانات النشر: | Springer link 2024-02-08T14:27:38Z 2024-02-08T14:27:38Z 2021-09-06 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Purpose/objective(s): Stereotactic body radiotherapy (SBRT) has become the standard of care for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC) and for patients who refuse surgery. The aim of this study was to evaluate the effectiveness and safety of primary SBRT in patients with early-stage NSCLC. Materials/methods: Retrospective multicenter study of 397 patients (416 primary lung tumours) treated with SBRT at 18 centres in Spain. 83.2% were men. The median age was 74.4 years. In 94.4% of cases, the tumour was inoperable. The pathological report was available in 54.6% of cases. SPSS vs 22.0. was used to perform all statistical analyses. Results: Complete response was obtained in 53.6% of cases. Significant prognostic factors were standard CT planning (p = 0.014) and 4D cone beam CT (p = 0.000). Acute and chronic toxicity ≥ grade 3 was observed in 1.2% of cases. At a median follow-up of 30 months, local relapse was 9.6%, lymph node relapse 12.8%, distant metastasis 16.6%, and another lung tumour 11.5%. Complete response was the only significant prognostic factor for local relapse (p = 0.012) and distant metastasis (p = 0.001). The local relapse-free survival was 88.7%. The overall survival was 75.7%. The cancer-specific survival was 92.7%. The disease-free survival was 78.7%. Conclusion: SBRT is an effective and well-tolerated treatment option for patients with early-stage lung cancer who are not suitable for surgery. The most important prognostic factor for local and distant recurrence was complete response, which in our sample depended on the type of CT planning and the IGRT technique. Depto. de Radiología, Rehabilitación y Fisioterapia Fac. de Medicina Universidad Complutense de Madrid TRUE pub |
| مصطلحات الفهرس: | 615.849.1, Lung cancer, Prognostic factors, SBRT, Ciencias Biomédicas, 32 Ciencias Médicas, journal article, CVoR |
| URL: | |
| الاتاحة: | Open access content. Open access content Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0 restricted access |
| ملاحظة: | application/pdf 1699-048X English |
| Other Numbers: | ESRCM oai:docta.ucm.es:20.500.14352/100490 Samper Ots, P.M., Vallejo Ocaña, C., Martin Martin, M. et al. Stereotactic body radiotherapy for early-stage non-small cell lung cancer: a multicentre study by the Oncologic Group for the Study of Lung Cancer (Spanish Radiation Oncology Society). Clin Transl Oncol 24, 342–349 (2022). https://doi.org/10.1007/s12094-021-02697-4 1699-048X 1699-3055 10.1007/s12094-021-02697-4 1429623051 |
| المصدر المساهم: | REPOSITORIO E-PRINTS UNIVERSIDAD COMPLU From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1429623051 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |