Electronic Resource
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| المؤلفون: | Sun, Zhi-Yan, Yang, Chang-Lin, Huang, Li-Jie, Mo, Zongchao, Zhang, Ke-Nan, Fan, Wen-Hua, Wang, Kuan-Yu, Wu, Fan, Wang, Ji-Guang, Meng, Fan-Lin, Zhao, Zheng, Jiang, Tao |
| بيانات النشر: | Oxford Univ Press 2024 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | circRNADisease v2.0 is an enhanced and reliable database that offers experimentally verified relationships between circular RNAs (circRNAs) and various diseases. It is accessible at http://cgga.org.cn/circRNADisease/ or http://cgga.org.cn:9091/circRNADisease/. The database currently includes 6998 circRNA-disease entries across multiple species, representing a remarkable 19.77-fold increase compared to the previous version. This expansion consists of a substantial rise in the number of circRNAs (from 330 to 4246), types of diseases (from 48 to 330) and covered species (from human only to 12 species). Furthermore, a new section has been introduced in the database, which collects information on circRNA-associated factors (genes, proteins and microRNAs), molecular mechanisms (molecular pathways), biological functions (proliferation, migration, invasion, etc.), tumor and/or cell line and/or patient-derived xenograft (PDX) details, and prognostic evidence in diseases. In addition, we identified 7 159 865 relationships between mutations and circRNAs among 30 TCGA cancer types. Due to notable enhancements and extensive data expansions, the circRNADisease 2.0 database has become an invaluable asset for both clinical practice and fundamental research. It enables researchers to develop a more comprehensive understanding of how circRNAs impact complex diseases. [Graphical Abstract] |
| مصطلحات الفهرس: | Article |
| URL: | |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| Other Numbers: | HNK oai:repository.hkust.edu.hk:1783.1-133662 Nucleic Acids Research, v. 52, (D1), January 2024, p. D1193-D1200 0305-1048 1362-4962 1422563125 |
| المصدر المساهم: | HONG KONG UNIV OF SCI & TECH, THE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1422563125 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |