Electronic Resource
BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle
| العنوان: | BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle |
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| المؤلفون: | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica, Delezie, Julien, Weihrauch, Martin, Maier, Geraldine, Tejero, Rocío, Ham, Daniel J., Gill, Jonathan F., Tabares, Lucía, Handschin, Christoph |
| بيانات النشر: | NATL ACAD SCIENCES 2019-07-18 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and likewise, affects the development of the neuromuscular system. Besides its neuronal origin, BDNF is also a member of the myokine family. However, the role of skeletal muscle-derived BDNF in regulating neuromuscular physiology in vivo remains unclear. Using gainand loss-of-function animal models, we show that muscle-specific ablation of BDNF shifts the proportion of muscle fibers from type IIB to IIX, concomitant with elevated slow muscle-type gene expression. Furthermore, BDNF deletion reduces motor end plate volume without affecting neuromuscular junction (NMJ) integrity. These morphological changes are associated with slow muscle function and a greater resistance to contraction-induced fatigue. Conversely, BDNF overexpression promotes a fast muscle-type gene program and elevates glycolytic fiber number. These findings indicate that BDNF is required for fiber-type specification and provide insights into its potential modulation as a therapeutic target in muscle diseases. |
| مصطلحات الفهرس: | Neurotrophic factor, Myokine, Oxidative fiber, Neuromuscular junction, Endurance exercise, info:eu-repo/semantics/article |
| URL: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (32), 16111-16120. |
| الاتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by-nc-nd/3.0/us info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América |
| ملاحظة: | English |
| Other Numbers: | SUE oai:idus.us.es:11441/146544 Delezie, J., Weihrauch, M., Maier, G., Tejero, R., Ham, D.J., Gill, J.F.,...,Handschin, C. (2019). BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (32), 16111-16120. https://doi.org/10.1073/pnas.1900544116. 0027-8424 10.1073/pnas.1900544116 1410781191 |
| المصدر المساهم: | UNIV DE SEVILLA From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1410781191 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |