Electronic Resource
Carbohydrate sulfotransferases: a review of emerging diagnostic and prognostic applications
| العنوان: | Carbohydrate sulfotransferases: a review of emerging diagnostic and prognostic applications |
|---|---|
| المؤلفون: | Begolli, Gramos, Marković, Ivana, Knežević, Jelena, Debeljak, Željko |
| المصدر: | Biochemia Medica; ISSN 1330-0962 (Print); ISSN 1846-7482 (Online); Volume 33; Issue 3 |
| بيانات النشر: | Croatian society of medical biochemistry and laboratory medicine 2023 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Carbohydrate sulfotransferases (CHST) catalyse the biosynthesis of proteoglycans that enable physical interactions and signalling between different neighbouring cells in physiological and pathological states. The study aim was to provide an overview of emerging diagnostic and prognostic applications of CHST. PubMed database search was conducted using the keywords “carbohydrate sulfotransferase” together with appropriate inclusion and exclusion criteria, whereby 41 publications were selected. Additionally, 40 records on CHST genetic and biochemical properties were hand-picked from UniProt, GeneCards, InterPro, and neXtProt databases. Carbohydrate sulfotransferases have been applied mainly in diagnostics of connective tissue disorders, cancer and inflammations. The lack of CHST activity was found in congenital connective tissue disorders while CHST overexpression was detected in different malignancies. Mutations of CHST3 gene cause skeletal dysplasia, chondrodysplasia, and autosomal recessive multiple joint dislocations while increased tissue expression of CHST11, CHST12 and CHST15 is an unfavourable prognostic factor in ovarian cancer, glioblastoma and pancreatic cancer, respectively. Recently, CHST11 and CHST15 overexpression in the vascular smooth muscle cells was linked to the severe lung pathology in COVID-19 patients. Promising CHST diagnostic and prognostic applications have been described but larger clinical studies and robust analytical procedures are required for the more reliable diagnostic performance estimations. |
| مصطلحات الفهرس: | cancer; carbohydrate sulfotransferases; connective tissue; inflammation; tumour markers, text, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | info:eu-repo/semantics/altIdentifier/doi/10.11613/BM.2023.030503 |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess Biochemia Medica is open access journal and all published articles are subject to CC-BY Creative Commons Attribution Licence which permits users to read, download, copy, distribute, print, search, or link to the full texts of these articles in any medium or format. Manuscript submission, article processing and publishing is free of charge and all copyrights to the manuscript are transferred to Biochemia Medica. The publisher (Croatian Society of Medical Biochemistry and Laboratory Medicine) has the right to reproduce and distribute the article in printed and electronic form. Journal is maintained and published with the financial support of the members of the Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM) and grants given by the Republic of Croatia’s Ministry of Science and Education. All Editorial work and peer-review are maintained voluntarily. Occasionally, Biochemia Medica may publish a promotional material and advertisement in order to promote sponsorship with emphasis on the special subjects from the field of Laboratory Medicine. |
| ملاحظة: | application/pdf English |
| Other Numbers: | HRCAK oai:hrcak.srce.hr:306658 1410375674 |
| المصدر المساهم: | HRCAK PORTAL ZNANSTVENIH CASOPISA REPUB From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1410375674 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |