Electronic Resource
Severe Immune-Related Adverse Events in Patients Treated with Nivolumab for Metastatic Renal Cell Carcinoma Are Associated with PDCD1 Polymorphism
| العنوان: | Severe Immune-Related Adverse Events in Patients Treated with Nivolumab for Metastatic Renal Cell Carcinoma Are Associated with PDCD1 Polymorphism |
|---|---|
| المؤلفون: | Kobayashi, Mizuki, Numakura, Kazuyuki, Hatakeyama, Shingo, Muto, Yumina, Sekine, Yuya, Sasagawa, Hajime, Kashima, Soki, Yamamoto, Ryohei, Koizumi, Atsushi, Nara, Taketoshi, Saito, Mitsuru, Narita, Shintaro, Ohyama, Chikara, Habuchi, Tomonori |
| بيانات النشر: | MDPI 2022 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Single nucleotide polymorphisms (SNPs) reportedly influence the effect of nivolumab in metastatic renal cell carcinoma (mRCC). This study aimed to evaluate the relationship between the clinical outcomes of patients with mRCC and SNPs in programmed cell death protein 1 (PD-1) protein-coding gene (PDCD1) and explore any potential correlation with patient prognosis and incidence of immune-related adverse events (irAEs). In total, 106 patients with mRCC, who were treated with nivolumab alone (n = 59) or nivolumab and ipilimumab (n = 47), were enrolled in the study. Three SNPs in the PDCD1 gene, namely PD-1.3, PD-1.5, and PD-1.6, were assessed. Patients harboring the PD-1.6 G allele experienced more severe (odds ratio, 3.390; 95% confidence interval 1.517-7.756; p = 0.003) and multiple (OR, 2.778; 95% CI, 1.020-6.993 p = 0.031) irAEs than those harboring the AA genotype. Thus, the existence of the PDCD1 PD-1.6 polymorphism (G allele) was associated with the occurrence of severe and multiple irAEs in patients with mRCC. Further evaluation of PDCD1 polymorphisms might help identify patients experiencing irAE by nivolumab treatment. |
| مصطلحات الفهرس: | single nucleotide polymorphism, PDCD1, nivolumab, adverse event, metastatic renal cell carcinoma, Journal Article, VoR |
| URL: | |
| الاتاحة: | Open access content. Open access content © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| ملاحظة: | application/pdf English |
| Other Numbers: | JPNII oai:irdb.nii.ac.jp:01474:0005696389 2073-4425 GENES, 13(7) 1409775315 |
| المصدر المساهم: | NATIONAL INST OF INFO From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1409775315 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |