Electronic Resource
FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice
| العنوان: | FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice |
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| المؤلفون: | Ojanen, M. J. (Markus J.T.), Caro, F. M. (Fernanda Munoz), Aittomäki, S. (Saara), Ploquin, M. J. (Mickaël J.), Ortutay, Z. (Zsuzsanna), Pekkarinen, M. (Meeri), Kesseli, J. (Juha), Vähätupa, M. (Maria), Määttä, J. (Juuso), Nykter, M. (Matti), Junttila, I. S. (Ilkka S.), Järvinen, T. A. (Tero A.H.), O´Shea, J. J. (John J.), Biron, C. A. (Christine A.), Pesu, M. (Marko) |
| بيانات النشر: | John Wiley & Sons 2023 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The proprotein convertase subtilisin/kexins (PCSKs) regulate biological actions by cleaving immature substrate proteins. The archetype PCSK, FURIN, promotes the pathogenicity of viruses by proteolytically processing viral proteins. FURIN has also important regulatory functions in both innate and adaptive immune responses but its role in the CD8+ CTLs remains enigmatic. We used a T-cell-specific FURIN deletion in vivo to demonstrate that FURIN promotes host response against the CTL-dependent lymphocytic choriomeningitis virus by virtue of restricting viral burden and augmenting interferon gamma (IFNG) production. We also characterized Furin KO CD8+ T cells ex vivo, including after their activation with FURIN regulating cytokines IL12 or TGFB1. Furin KO CD8+ T cells show an inherently activated phenotype characterized by the upregulation of effector genes and increased frequencies of CD44+, TNF+, and IFNG+ cells. In the activated CTLs, FURIN regulates the productions of IL2, TNF, and GZMB and the genes associated with the TGFBR-signaling pathway. FURIN also controls the expression of Eomes, Foxo1, and Bcl6 and the levels of ITGAE and CD62L, which implies a role in the development of CTL memory. Collectively, our data suggest that the T-cell expressed FURIN is important for host responses in viral infections, CTL homeostasis/activation, and memory development. |
| مصطلحات الفهرس: | CD8+ T-cell, FURIN, LCMV, T-cell memory, adaptive immune system, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
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| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess © 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0 |
| ملاحظة: | application/pdf English |
| Other Numbers: | OUX oai:oulu.fi:nbnfi-fe20230922136207 urn:nbn:fi-fe20230922136207 1405224252 |
| المصدر المساهم: | UNIV OF OULU From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1405224252 |
| قاعدة البيانات: | OAIster |
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