Electronic Resource
Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin
| العنوان: | Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin |
|---|---|
| المؤلفون: | Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica, Abal Camaño, Paula, Louzao Ojeda, María Carmen, Vilariño del Río, Natalia, Rodríguez Vieytes, María Mercedes, Botana López, Luis Miguel |
| بيانات النشر: | MDPI 2019 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Tetrodotoxin (TTX) is an extremely toxic marine compound produced by different genera of bacteria that can reach humans through ingestion mainly of pufferfish but also of other contaminated fish species, marine gastropods or bivalves. TTX blocks voltage-gated sodium channels inhibiting neurotransmission, which in severe cases triggers cardiorespiratory failure. Although TTX has been responsible for many human intoxications limited toxicological data are available. The recent expansion of TTX from Asian to European waters and diversification of TTX-bearing organisms entail an emerging risk of food poisoning. This study is focused on the acute toxicity assessment of TTX administered to mice by oral gavage following macroscopic and microscopic studies. Necropsy revealed that TTX induced stomach swelling 2 h after administration, even though no ultrastructural alterations were further detected. However, transmission electron microscopy images showed an increase of lipid droplets in hepatocytes, swollen mitochondria in spleens, and alterations of rough endoplasmic reticulum in intestines as hallmarks of the cellular damage. These findings suggested that gastrointestinal effects should be considered when evaluating human TTX poisoning. |
| مصطلحات الفهرس: | Tetrodotoxin, Macroscopic alterations, Ultrastructural changes, Gastrointestinal effect, Mitochondria swelling, Rough endoplasmic reticulum swelling, journal article |
| URL: | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-58210-R/ES/EVALUACION DE LA SEGURIDAD ALIMENTARIA DE PRODUCTOS PESQUEROS ASOCIADA A LA PRESENCIA DE TOXINAS MARINAS DE NUEVA APARICION EN AGUAS EUROPEAS info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-78728-R/ES |
| الاتاحة: | Open access content. Open access content https://creativecommons.org/licenses/by/4.0 open access © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) |
| ملاحظة: | English |
| Other Numbers: | ESUSC oai:minerva.usc.es:10347/21203 Abal, P., Louzao, M.C., Vilariño, N., Vyeites, M.R., Botana, L.M. (2019). Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin. "Toxins", 11(6), 305 10.3390/toxins11060305 2072-6651 1400976622 |
| المصدر المساهم: | UNIVERSIDADE DE SANTIAGO DE COMPOSTELA From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1400976622 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |