Electronic Resource
Elucidating Regulatory Events Along GC-1
| العنوان: | Elucidating Regulatory Events Along GC-1 |
|---|---|
| المؤلفون: | Horton, Nancy, Jewett, John, Langlais, Paul, Gorczyca, Amanda |
| بيانات النشر: | The University of Arizona. 2023 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Guanylyl Cyclase-1 (GC-1), or soluble guanylyl cyclase (sGC), is a heterodimeric heme-containing protein that responds to the binding of nitric oxide (NO) with enhanced cyclase activity, producing cyclic guanosine monophosphate (cGMP) and a signaling cascade. NO regulates numerous physiological processes, including platelet aggregation, memory formation, sexual function, blood pressure homeostasis, and immune response. Dysfunction along the NO/GC- 1/cGMP pathway is a crucial component in multiple cardiovascular diseases, namely pulmonary hypertension, insufficient platelet aggregation, heart failure, and stroke. Therefore, GC-1 is heavily targeted for drug discovery. Stimulation of the NO signaling pathway has been used therapeutically to treat various forms of cardiovascular disease for more than a century, beginning with the administration of amyl nitrite and nitroglycerin to relieve symptoms of angina pectoris. Despite its significance to cardiovascular health and disease, the structure, regulation, and function of GC-1 remains poorly understood. This work describes the solvent accessibility of GC- 1 using hydroxyl radical footprinting coupled with tandem mass spectrometry, as well as the effect of phosphorylation sites along full-length GC-1 |
| مصطلحات الفهرس: | Electronic Dissertation, text |
| URL: | |
| الاتاحة: | Open access content. Open access content http://rightsstatements.org/vocab/InC/1.0 Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
| Other Numbers: | AZU oai:repository.arizona.edu:10150/669800 Gorczyca, Amanda. (2023). Elucidating Regulatory Events Along GC-1 (Doctoral dissertation, University of Arizona, Tucson, USA). 1397524145 |
| المصدر المساهم: | UNIV OF ARIZONA From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1397524145 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |