Electronic Resource
Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography.
| العنوان: | Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography. |
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| المؤلفون: | Sergeev, Maxim E, Sergeev, Maxim E, Lazari, Mark, Morgia, Federica, Collins, Jeffrey, Javed, Muhammad Rashed, Sergeeva, Olga, Jones, Jason, Phelps, Michael E, Lee, Jason T, Keng, Pei Yuin, van Dam, R Michael |
| المصدر: | Communications chemistry; vol 1, iss 1, 10; 2399-3669 |
| بيانات النشر: | eScholarship, University of California 2018-01-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Positron emission tomography (PET) is a molecular diagnostic imaging technology to quantitatively visualize biological processes in vivo. For many applications, including imaging of low tissue density targets (e.g. neuroreceptors), imaging in small animals, and evaluation of novel tracers, the injected PET tracer must be produced with high molar activity to ensure low occupancy of biological targets and avoid pharmacologic effects. Additionally, high molar activity is essential for tracers with lengthy syntheses or tracers transported to distant imaging sites. We show that radiosynthesis of PET tracers in microliter volumes instead of conventional milliliter volumes results in substantially increased molar activity, and we identify the most relevant variables affecting this parameter. Furthermore, using the PET tracer [18F]fallypride, we illustrate that molar activity can have a significant impact on biodistribution. With full automation, microdroplet platforms could provide a means for radiochemists to routinely, conveniently, and safely produce PET tracers with high molar activity. |
| مصطلحات الفهرس: | Bioengineering, Biomedical Imaging, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, article |
| URL: | |
| الاتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Communications chemistry vol 1, iss 1, 10 2399-3669 |
| Other Numbers: | CDLER oai:escholarship.org:ark:/13030/qt4z99v1zb qt4z99v1zb https://escholarship.org/uc/item/4z99v1zb https://escholarship.org/ 1391601929 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391601929 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |