Electronic Resource
[18F]FMCH PET/CT biomarkers and similarity analysis to refine the definition of oligometastatic prostate cancer
| العنوان: | [18F]FMCH PET/CT biomarkers and similarity analysis to refine the definition of oligometastatic prostate cancer |
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| المؤلفون: | Sollini, M, Bartoli, F, Cavinato, L, Ieva, F, Ragni, A, Marciano, A, Zanca, R, Galli, L, Paiar, F, Pasqualetti, F, Erba, P, Sollini M., Bartoli F., Cavinato L., Ieva F., Ragni A., Marciano A., Zanca R., Galli L., Paiar F., Pasqualetti F., Erba P. A. |
| بيانات النشر: | Springer Science and Business Media Deutschland GmbH country:DE 2021 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: The role of image-derived biomarkers in recurrent oligometastatic Prostate Cancer (PCa) is unexplored. This paper aimed to evaluate [18F]FMCH PET/CT radiomic analysis in patients with recurrent PCa after primary radical therapy. Specifically, we tested intra-patient lesions similarity in oligometastatic and plurimetastatic PCa, comparing the two most used definitions of oligometastatic disease. Methods: PCa patients eligible for [18F]FMCH PET/CT presenting biochemical failure after first-line curative treatments were invited to participate in this prospective observational trial. PET/CT images of 92 patients were visually and quantitatively analyzed. Each patient was classified as oligometastatic or plurimetastatic according to the total number of detected lesions (up to 3 and up to 5 or > 3 and > 5, respectively). Univariate and intra-patient lesions' similarity analysis were performed. Results: [18F]FMCH PET/CT identified 370 lesions, anatomically classified as regional lymph nodes and distant metastases. Thirty-eight and 54 patients were designed oligometastatic and plurimetastatic, respectively, using a 3-lesion threshold. The number of oligometastic scaled up to 60 patients (thus 32 plurimetastatic patients) with a 5-lesion threshold. Similarity analysis showed high lesions' heterogeneity. Grouping patients according to the number of metastases, patients with oligometastatic PCa defined with a 5-lesion threshold presented lesions heterogeneity comparable to plurimetastic patients. Lesions within patients having a limited tumor burden as defined by three lesions were characterized by less heterogeneity. Conclusions: We found a comparable heterogeneity between patients with up to five lesions and plurimetastic patients, while patients with up to three lesions were less heterogeneous than plurimetastatic patients, featuring different cells phenotypes in the two groups. Our results supported the use of a 3-lesion threshold to define oligometastati |
| مصطلحات الفهرس: | Biomarker, Epithelial-mesenchymal transition, Number of lesion, Oligometastatic PCa, Radiomic, Silhouette index, Similarity analysi, [, 18, F]FMCH PET/CT, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/34837532 info:eu-repo/semantics/altIdentifier/wos/WOS:000722984000001 volume:11 issue:1 journal:EJNMMI RESEARCH |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | ELETTRONICO English |
| Other Numbers: | ITBAO oai:boa.unimib.it:10281/419618 10.1186/s13550-021-00858-8 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85119973406 1383766159 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1383766159 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |