Electronic Resource
TUBectomy with delayed oophorectomy as an alternative to risk-reducing salpingo-oophorectomy in high-risk women to assess the safety of prevention: the TUBA-WISP II study protocol
| العنوان: | TUBectomy with delayed oophorectomy as an alternative to risk-reducing salpingo-oophorectomy in high-risk women to assess the safety of prevention: the TUBA-WISP II study protocol |
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| المؤلفون: | Steenbeek, M, van Bommel, M, Inthout, J, Peterson, C, Simons, M, Roes, K, Kets, M, Norquist, B, Swisher, E, Hermens, R, Lu, K, de Hullu, J, Fruscio, R, Steenbeek, Miranda P, van Bommel, Majke H D, intHout, Joanna, Peterson, Christine B, Simons, Michiel, Roes, Kit C B, Kets, Marleen, Norquist, Barbara M, Swisher, Elizabeth M, Hermens, Rosella P M G, Lu, Karen H, de Hullu, Joanne A, Fruscio, Robert |
| بيانات النشر: | BMJ Group country:US 2023 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Risk-reducing salpingectomy with delayed oophorectomy has gained interest for individuals at high risk for tubo-ovarian cancer as there is compelling evidence that especially high-grade serous carcinoma originates in the fallopian tubes. Two studies have demonstrated a positive effect of salpingectomy on menopause-related quality of life and sexual health compared with standard risk-reducing salpingo-oophorectomy. Primary Objective: To investigate whether salpingectomy with delayed oophorectomy is non-inferior to the current standard salpingo-oophorectomy for the prevention of tubo-ovarian cancer among individuals at high inherited risk. Study Hypothesis: We hypothesize that postponement of oophorectomy after salpingectomy, to the age of 40-45 (BRCA1) or 45-50 (BRCA2) years, compared with the current standard salpingo-oophorectomy at age 35-40 (BRCA1) or 40-45 (BRCA2) years, is non-inferior in regard to tubo-ovarian cancer risk. Trial Design: In this international prospective preference trial, participants will choose between the novel salpingectomy with delayed oophorectomy and the current standard salpingo-oophorectomy. Salpingectomy can be performed after the completion of childbearing and between the age of 25 and 40 (BRCA1), 25 and 45 (BRCA2), or 25 and 50 (BRIP1, RAD51C, and RAD51D pathogenic variant carriers) years. Subsequent oophorectomy is recommended at a maximum delay of 5 years beyond the upper limit of the current guideline age for salpingo-oophorectomy. The current National Comprehensive Cancer Network (NCCN) guideline age, which is also the recommended age for salpingo-oophorectomy within the study, is 35-40 years for BRCA1, 40-45 years for BRCA2, and 45-50 years for BRIP1, RAD51C, and RAD51D pathogenic variant carriers. Major Inclusion/Exclusion Criteria: Premenopausal individuals with a documented class IV or V germline pathogenic variant in the BRCA1, BRCA2, BRIP1, RAD51C, or RAD51D gene who have completed childbearing are eligible for |
| مصطلحات الفهرس: | BRCA1 Protein, BRCA2 Protein, Carcinoma, Gynecologic Surgical Procedure, Ovarian Cancer, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/37045546 info:eu-repo/semantics/altIdentifier/wos/WOS:000976755000001 volume:33 issue:6 firstpage:982 lastpage:987 numberofpages:6 journal:INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | ELETTRONICO English |
| Other Numbers: | ITBAO oai:boa.unimib.it:10281/419543 10.1136/ijgc-2023-004377 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85159208679 1383765924 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1383765924 |
| قاعدة البيانات: | OAIster |
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