Electronic Resource
Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia:A Study by the International Berlin-Frankfurt-Munster Study Group
| العنوان: | Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia:A Study by the International Berlin-Frankfurt-Munster Study Group |
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| المؤلفون: | van Weelderen, Romy E., Klein, Kim, Harrison, Christine J., Jiang, Yilin, Abrahamsson, Jonas, Arad-Cohen, Nira, Bart-Delabesse, Emmanuelle, Buldini, Barbara, De Moerloose, Barbara, Dworzak, Michael N., Elitzur, Sarah, Fernández Navarro, José M., Gerbing, Robert B., Goemans, Bianca F., de Groot-Kruseman, Hester A., Guest, Erin, Ha, Shau Yin, Hasle, Henrik, Kelaidi, Charikleia, Lapillonne, Hélène, Leverger, Guy, Locatelli, Franco, Masetti, Riccardo, Miyamura, Takako, Norén-Nyström, Ulrika, Polychronopoulou, Sophia, Rasche, Mareike, Rubnitz, Jeffrey E., Stary, Jan, Tierens, Anne, Tomizawa, Daisuke, Zwaan, C. Michel, Kaspers, Gertjan J.L. |
| المصدر: | van Weelderen , R E , Klein , K , Harrison , C J , Jiang , Y , Abrahamsson , J , Arad-Cohen , N , Bart-Delabesse , E , Buldini , B , De Moerloose , B , Dworzak , M N , Elitzur , S , Fernández Navarro , J M , Gerbing , R B , Goemans , B F , de Groot-Kruseman , H A , Guest , E , Ha , S Y , Hasle , H , Kelaidi , C , Lapillonne , H , Leverger , G , Locatelli , F , Masetti , R , Miyamura , T , Norén-Nyström , U , Polychronopoulou , S , Rasche , M , Rubnitz , J E , Stary , J , Tierens , A , Tomizawa , D , Zwaan , C M & Kaspers , G J L 2023 , ' Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia : A Study by the International Berlin-Frankfurt-Munster Study Group ' , Journal of clinical oncology : official journal of the American Society of Clinical Oncology , vol. 41 , no. 16 , pp. 2963-2974 . |
| بيانات النشر: | 2023-06-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | PURPOSE: A previous study by the International Berlin-Frankfurt-Münster Study Group (I-BFM-SG) on childhood KMT2A-rearranged (KMT2A-r) AML demonstrated the prognostic value of the fusion partner. This I-BFM-SG study investigated the value of flow cytometry-based measurable residual disease (flow-MRD) and evaluated the benefit of allogeneic stem-cell transplantation (allo-SCT) in first complete remission (CR1) in this disease. METHODS: A total of 1,130 children with KMT2A-r AML, diagnosed between January 2005 and December 2016, were assigned to high-risk (n = 402; 35.6%) or non-high-risk (n = 728; 64.4%) fusion partner-based groups. Flow-MRD levels at both end of induction 1 (EOI1) and 2 (EOI2) were available for 456 patients and were considered negative (<0.1%) or positive (≥0.1%). End points were 5-year event-free survival (EFS), cumulative incidence of relapse (CIR), and overall survival (OS). RESULTS: The high-risk group had inferior EFS (30.3% high risk v 54.0% non-high risk; P < .0001), CIR (59.7% v 35.2%; P < .0001), and OS (49.2% v 70.5%; P < .0001). EOI2 MRD negativity was associated with superior EFS (n = 413; 47.6% MRD negativity v n = 43; 16.3% MRD positivity; P < .0001) and OS (n = 413; 66.0% v n = 43; 27.9%; P < .0001), and showed a trend toward lower CIR (n = 392; 46.1% v n = 26; 65.4%; P = .016). Similar results were obtained for patients with EOI2 MRD negativity within both risk groups, except that within the non-high-risk group, CIR was comparable with that of patients with EOI2 MRD positivity. Allo-SCT in CR1 only reduced CIR (hazard ratio, 0.5 [95% CI, 0.4 to 0.8]; P = .00096) within the high-risk group but did not improve OS. In multivariable analyses, EOI2 MRD positivity and high-risk group were independently associated with inferior EFS, CIR, and OS. CONCLUSION: EOI2 flow-MRD is an independent prognostic factor and should be included as risk stratification factor in childhood KMT2A-r AML. Treatment approaches other than all |
| مصطلحات الفهرس: | dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being, article |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| Other Numbers: | QGQ oai:pure.eur.nl:publications/d91778f2-d863-42bc-a447-a84c2da899dd https://pure.eur.nl/en/publications/d91778f2-d863-42bc-a447-a84c2da899dd https://doi.org/10.1200/JCO.22.02120 https://pure.eur.nl/ws/files/93216143/Measurable_Residual_Disease_and_Fusion_Partner_Independently_Predict_Survival_and_Relapse_Risk_in_Childhood_KMT2A_Rearranged_Acute_Myeloid_Leukemia.pdf 1383761119 |
| المصدر المساهم: | ERASMUS UNIVERSITEIT ROTTERDAM From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1383761119 |
| قاعدة البيانات: | OAIster |
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