Electronic Resource
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains:[Inkl. Correction]
| العنوان: | Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains:[Inkl. Correction] |
|---|---|
| المؤلفون: | Demontis, Ditte, Walters, G. Bragi, Athanasiadis, Georgios, Walters, Raymond, Therrien, Karen, Nielsen, Trine Tollerup, Farajzadeh, Leila, Voloudakis, Georgios, Bendl, Jaroslav, Zeng, Biau, Zhang, Wen, Grove, Jakob, Als, Thomas D., Duan, Jinjie, Satterstrom, F. Kyle, Bybjerg-Grauholm, Jonas, Bækved-Hansen, Marie, Gudmundsson, Olafur O., Magnusson, Sigurdur H., Baldursson, Gisli, Davidsdottir, Katrin, Haraldsdottir, Gyda S., Agerbo, Esben, Hoffman, Gabriel E., Dalsgaard, Søren, Martin, Joanna, Ribasés, Marta, Boomsma, Dorret I., Soler Artigas, Maria, Roth Mota, Nina, Howrigan, Daniel, Medland, Sarah E., Zayats, Tetyana, Rajagopal, Veera M., Havdahl, Alexandra, Doyle, Alysa, Reif, Andreas, Thapar, Anita, Cormand, Bru, Liao, Calwing, Burton, Christie, Bau, Claiton H.D., Rovaris, Diego Luiz, Sonuga-Barke, Edmund, Corfield, Elizabeth, Grevet, Eugenio Horacio, Larsson, Henrik, Gizer, Ian R., Nordentoft, Merete, Werge, Thomas |
| المصدر: | Demontis , D , Walters , G B , Athanasiadis , G , Walters , R , Therrien , K , Nielsen , T T , Farajzadeh , L , Voloudakis , G , Bendl , J , Zeng , B , Zhang , W , Grove , J , Als , T D , Duan , J , Satterstrom , F K , Bybjerg-Grauholm , J , Bækved-Hansen , M , Gudmundsson , O O , Magnusson , S H , Baldursson , G , Davidsdottir , K , Haraldsdottir , G S , Agerbo , E , Hoffman , G E , Dalsgaard , S , Martin , J , Ribasés , M , Boomsma , D I , Soler Artigas , M , Roth Mota , N , Howrigan , D , Medland , S E , Zayats , T , Rajagopal , V M , Havdahl , A , Doyle , A , Reif , A , Thapar , A , Cormand , B , Liao , C , Burton , C , Bau , C H D , Rovaris , D L , Sonuga-Barke , E , Corfield , E , Grevet , E H , Larsson , H , Gizer , I R , Nordentoft , M , Werge , T , ADHD Working Group of the Psychiatric Genomics Consortium & iPSYCH-Broad Consortium 2023 , ' Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains : [Inkl. Correction] ' , Nature Genetics , vol. 55 , pp. 198–208 . |
| بيانات النشر: | 2023 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders. In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention. |
| مصطلحات الفهرس: | article |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/closedAccess |
| ملاحظة: | application/pdf English |
| Other Numbers: | DAV oai:pure.atira.dk:publications/4e97603e-8b6b-4a60-b607-130cdf782191 1382516186 |
| المصدر المساهم: | UNIV OF COPENHAGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1382516186 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |