Electronic Resource
Double-Strand Break Repair in Repetitive DNA Regions
| العنوان: | Double-Strand Break Repair in Repetitive DNA Regions |
|---|---|
| المؤلفون: | Delvaux de Fenffe, Charlotte, Janssen, Aniek (Thesis Advisor) |
| بيانات النشر: | Utrecht University 2023 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Every day, our cells are exposed to endogenous and exogenous sources of damage which cause double-strand breaks (DSBs). If left unrepaired or misrepaired, DBSs can be highly toxic for the cell resulting in cell death, mutations, or genomic instability, which is a hallmark of cancer development. To deal with such breaks, the cell activates the DNA damage response which will sense the DSB and activate the appropriate repair pathway. Two main repair pathways exist: non-homologous end-joining and homologous recombination. The choice of repair pathway is dependent on different factors such as the cell cycle phase and the chromatin context in which the break occurred. Moreover, the different chromatin organizations will recruit different repair proteins and lead to different repair mechanisms as a way of safeguarding genomic stability. However, in highly repetitive regions of the DNA, such as in constitutive heterochromatin, ribosomal DNA, and centromeres, there are higher risks of aberrant recombination and chromosomal rearrangement occurring during repair due to their repetitive nature. Even though these repetitive regions pose a particular danger to our genome integrity, repetitive elements cover half of our genome. It is therefore essential that the cell ensures proper repair in repetitive DNA regions to maintain genomic integrity. In this review, we give an overview of the current knowledge of the different ways repetitive DNA regions are repaired after DSBs specifically in heterochromatin, ribosomal DNA, and centromeres. |
| مصطلحات الفهرس: | In this review, we give an overview of the current knowledge in the field of DSB repair in repetitive sequences. Here, we describe the DSB repair mechanisms used in the three repetitive DNA regions (centromeres, heterochromatin, and ribosomal DNA) to safeguard their genetic information, mainly focusing on research from mammalian cells and Drosophila. We discuss the different repair pathways that are preferred in each region and the mechanisms that the cell uses to avoid aberrant recombination., Master Thesis, Student Thesis |
| URL: | |
| الاتاحة: | Open access content. Open access content CC-BY-NC-ND Open Access |
| ملاحظة: | EN |
| Other Numbers: | QGJ oai:studenttheses.uu.nl:20.500.12932/43692 https://studenttheses.uu.nl/handle/20.500.12932/43692 1382388503 |
| المصدر المساهم: | UNIVERSITEIT UTRECHT From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1382388503 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |