Electronic Resource
A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy
| العنوان: | A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy |
|---|---|
| المؤلفون: | 1000050781267, Fukunaga, Hisanori, Butterworth, K. T., McMahon, S. J., Prise, K. M. |
| بيانات النشر: | Elsevier 2021-11 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Microbeam radiotherapy (MRT) is the delivery of spatially fractionated beams that have the potential to offer significant improvements in the therapeutic ratio due to the delivery of micron-sized high dose and dose rate beams. They build on longstanding clinical experience of GRID radiotherapy and more recently lattice-based approaches. Here we briefly overview the preclinical evidence for MRT efficacy and highlight the challenges for bringing this to clinical utility. The biological mechanisms underpinning MRT efficacy are still unclear, but involve vascular, bystander, stem cell and potentially immune responses. There is probably significant overlap in the mechanisms underpinning MRT responses and FLASH radiotherapy that needs to be further defined. (c) 2021 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. |
| مصطلحات الفهرس: | Bystander effects, grid therapy, microbeam radiotherapy, vascular damage, 490, Journal Article, NA |
| URL: | |
| الاتاحة: | Open access content. Open access content metadata only access |
| ملاحظة: | English |
| Other Numbers: | JPNII oai:irdb.nii.ac.jp:01364:0005203815 0936-6555 Clinical Oncology, 33(11), 705-712 1375192836 |
| المصدر المساهم: | NATIONAL INST OF INFO From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1375192836 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |