Electronic Resource
Successful oral prime-immunization with VP60 from rabbit haemorrhagic disease virus produced in transgenic plants using different fusion strategies
| العنوان: | Successful oral prime-immunization with VP60 from rabbit haemorrhagic disease virus produced in transgenic plants using different fusion strategies |
|---|---|
| المؤلفون: | Gil, Félix, Titarenko, E., Terrada, E., Arcalís, E., Escribano, J. M. |
| بيانات النشر: | John Wiley & Sons 2006 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Expression levels of vaccine antigens in transgenic plants have important consequences in their use as edible vaccines. The major structural protein VP60 from the rabbit haemorrhagic disease virus (RHDV) has been produced in transgenic plants using different strategies to compare its accumulation in plant tissues. The highest expressing plants were those presenting stable, complex, high-density structures formed by VP60, suggesting the importance of multisubunit structures for the stability of this protein in plant cells. Mice fed with leaves of transgenic plants expressing VP60 were primed to a subimmunogenic baculovirus-derived vaccine single dose. This indicates that plants expressing VP60 antigen may be a new means for oral RHDV immunization. © 2005 Blackwell Publishing Ltd. |
| مصطلحات الفهرس: | Capsid protein, Plantmade vaccine, Rabbit haemorrhagic disease virus, Transgenic plants, artículo |
| URL: | Departamento de Biotecnología Sí |
| الاتاحة: | Open access content. Open access content closedAccess |
| ملاحظة: | English |
| Other Numbers: | CTK oai:digital.csic.es:10261/294901 Plant Biotechnology Journal 4: 135-143 (2006) 1467-7644 10.1111/j.1467-7652.2005.00172.x 1467-7652 1373158109 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1373158109 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |