Electronic Resource
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
| العنوان: | Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue |
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| المؤلفون: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, Ministerio de Economía y Competitividad (España), Fundació La Marató de TV3, European Foundation for the Study of Diabetes, Novo Nordisk Foundation, European Commission, Centro Esther Koplowitz, González-Franquesa, Alba, Gama-Pérez, Pau, Kulis, Marta, Szczepanowska, Karolina, Dahdah, Norma, Moreno-Gomez, Sonia, Latorre-Pellicer, Ana, Fernández-Ruiz, Rebeca, Aguilar-Mogas, Antoni, Hoffman, Anne, Monelli, Erika, Samino, Sara, Miró-Blanch, Joan, Oemer, Gregor, Durán, Xavier, Sanchez-Rebordelo, Estrella, Schneeberger, Marc, Obach, Merce, Montane, Joel, Castellano, Giancarlo, Chapaprieta, Vicente, Sun, Wenfei, Navarro, Lourdes, Prieto, Ignacio, Castaño, Carlos, Novials, Anna, Gomis, Ramón, Monsalve, María, Claret, Marc, Graupera, Mariona, Soria, Guadalupe, Wolfrum, Christian, Vendrell, Joan, Fernández-Veledo, Sonia, Enríquez, José Antonio, Perales, José Carlos, Nogueiras, Rubén, Herrero, Laura, Trifunovic, Aleksandra, Keller, Markus A., Yanes, Óscar, Sales-Pardo, Marta, Guimerà, Roger, Blüher, Matthias, Martín-Subero, José Ignacio, Garcia-Roves, Pablo M. |
| بيانات النشر: | Elsevier 2022-08 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue. |
| مصطلحات الفهرس: | Obesity, Metabolic plasticity, Visceral adipose tissue, Mitochondrial dysfunction, Exercise, Caloric restriction, Multi-organ approach, Human obesity, Two-steps bariatric surgery, Metabolic fingerprint, artículo |
| URL: | Publisher's version Sí info:eu-repo/grantAgreement/MICINN//BFU2011-24679/ES/DESCIFRANDO LA RESPUESTA INTEGRAL CAPAZ DE RESTITUIR LA NORMOGLUCEMIA EN RATONES CON DIABETES TIPO 2 DEBIDO A CAMBIOS EN SU ESTILO DE VIDA (DIETA Y%2FO EJERCICIO) info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093864-B-I00/ES/APLICACION DE LA MEDIDA DE LA PLASTICIDAD METABOLICA&8194 AL DIAGNOSTICO Y SEGUIMIENTO DE LA RESPUESTA AL TRATAMIENTO EN ENFERMEDADES CRONICAS info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-87958-P/ES/LA INTERACCION ENTRE MICROBIOTA Y METABOLISMO DEL HUESPED REGULA LA EPIGENETICA DEL HUESPED info:eu-repo/grantAgreement/MINECO//SAF2013-45887-R/ES/POTENCIACION DEL PODER DE QUEMAR GRASAS DEL TEJIDO ADIPOSO MARRON COMO TERAPIA CONTRA LA OBESIDAD Y LA DIABETES info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83813-C3-1-R/ES/MODULACION DEL METABOLISMO LIPIDICO PERIFERICO Y CENTRAL PARA REDUCIR LA INGESTA Y LA OBESIDAD info:eu-repo/grantAgreement/MICINN//RYC-2009-05158/ES/RYC-2009-05158 info:eu-repo/grantAgreement/EC/H2020/675610 info:eu-repo/grantAgreement/MINECO//BES-2013-062796/ES/BES-2013-062796 |
| الاتاحة: | Open access content. Open access content https://creativecommons.org/licenses/by/4.0 openAccess |
| Other Numbers: | CTK oai:digital.csic.es:10261/290334 Redox Biology 54: 102353 (2022) 10.1016/j.redox.2022.102353 1373152755 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1373152755 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |