Electronic Resource
Maytansinol functionalization:towards useful probes for studying microtubule dynamics
| العنوان: | Maytansinol functionalization:towards useful probes for studying microtubule dynamics |
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| المؤلفون: | European Commission, Ministerio de Ciencia e Innovación (España), Boiarska, Zlata [0000-0003-1235-5717], Abel, Anne-Catherine [0000-0002-2392-9029], Marzullo, Paola [0000-0003-4249-8794], Álvarez-Bernad, Beatriz [0000-0002-2492-9215], Bonato, Francesca [0000-0002-0579-2874], Horvath, Dragos [0000-0003-0173-5714], Lucena-Agell, Daniel [0000-0001-7198-2900], Vasile, Francesca [0000-0002-3926-8261], Sironi, Maurizio [0000-0001-5822-4849], Díaz, José Fernando [0000-0003-2743-3319], Prota, Andrea E. [0000-0003-0875-5339], Pieraccini, Stefano [0000-0002-7672-0720], Passarella, D. [0000-0001-6180-9581], Boiarska, Zlata, Pérez-Peña, Helena, Abel, Anne-Catherine, Marzullo, Paola, Álvarez-Bernad, Beatriz, Bonato, Francesca, Santini, Benedetta, Horvath, Dragos, Lucena-Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Díaz, José Fernando, Prota, Andrea E., Pieraccini, Stefano, Passarella, D. |
| بيانات النشر: | John Wiley & Sons 2023-01-24 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Maytansinoids are a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics has been held back by the complexity of natural product chemistry. Here we report the synthesis of long-chain derivatives and maytansinoid conjugates. We confirmed that bulky substituents do not impact their high activity or the scaffold's binding mode. These encouraging results open new avenues for the design of new maytansine-based probes. |
| مصطلحات الفهرس: | artículo |
| URL: | Sí info:eu-repo/grantAgreement/EC/H2020/860070 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104545RB-I00 |
| الاتاحة: | Open access content. Open access content closedAccess |
| ملاحظة: | English |
| Other Numbers: | CTK oai:digital.csic.es:10261/287829 Chemistry - a European Journal 29 (5) e202203431 (2023) 0947-6539 10.1002/chem.202203431 1521-3765 1373150374 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1373150374 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |