Electronic Resource
Repositioning Adequate Antibiotics to Treat/Cure the Coronavirus Disease 2019 (COVID-19): Current Treatments and Future Directions
| العنوان: | Repositioning Adequate Antibiotics to Treat/Cure the Coronavirus Disease 2019 (COVID-19): Current Treatments and Future Directions |
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| المؤلفون: | UCL - SSS/LDRI - Louvain Drug Research Institute, Hountondji, Codjo, Besnaïnou, Gilles, Gaudet, Eugène, Poupaert, Jacques |
| المصدر: | The Open Biochemistry Journal, Vol. 15, no.1, p. 1-19 (2021) |
| بيانات النشر: | Bentham Science Publishers Ltd. 2021 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | AIMS: Rational use of antibiotics against the betacoronavirus SARS-CoV-2 responsible for the COVID-19 pandemic. OBJECTIVE : Repositioning and repurposing adequate antibiotics to cure the Coronavirus Disease 2019 (COVID-19). BACKGROUND : It is widely accepted that viral infections such as the SARS-CoV-2 cannot be cured by antibiotics, whereas bacterial infections can. It is because the SARS-CoV-2 virus has no protein synthesis machinery (usually targeted by antibiotics) to produce from its RNA genome, the viral proteins and enzymes essential for its replication and/or for the assembly of viral particles. However, the antibiotics must be capable of inhibiting the ribosomes of the protein synthesis machinery of the SARS-CoV-2-infected human host cells, in order to prevent them from synthesizing new proteins that they do not need, but are needed for the virus to spread. Unfortunately, the only antibiotic capable of selectively inhibiting the human 80S ribosomes, namely cycloheximide, was found to be a poisonous drug for the mammals. Therefore, the only possibility is to search for the antibiotics that are capable of inhibiting both bacterial and eukaryal ribosomes, in order to prevent at the same time the ribosomes of the infected human host cells from synthesizing the proteins and enzymes for the SARS-CoV-2 virus, and those of the eventual opportunistic pathogenic bacteria from developing pneumonia. METHODS: First, we have used a molecular modeling study involving the tools of the semi-empirical quantum mechanics PM3 method to study the interaction between the cation Zn++ and all the molecules considered as zinc transporters in this report. By this approach, the niche in which Zn++ is located was determined. Such an interaction serves as a shuttle and allows zinc cation to invade endocellular structures in the SARS-CoV-2-infected human host cells. Second, we have measured the poly (U)-dependent poly (Phe) synthesis activity of human 80S ribosomes in the presence of inc |
| مصطلحات الفهرس: | General Biochemistry, Genetics and Molecular Biology, Coronavirus SARS-CoV-2 and COVID-19, Antibiotics Macrolides and Tetracyclines, Repositioning adequate antibiotics, Translating Human 80S and E. coli 70S ribosomes, The A-site and the protein exit tunnel, Macrolides and Tetracyclines as zinc cation binding antibiotics, info:eu-repo/semantics/article |
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| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | English |
| Other Numbers: | UCDLC oai:dial.uclouvain.be:boreal:268368 boreal:268368 info:doi/10.2174/1874091x02115010001 urn:EISSN:1874-091X 1372937043 |
| المصدر المساهم: | UNIVERSITE CATHOLIQUE DE LOUVAIN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1372937043 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |