Electronic Resource
Comparing Treatment Outcomes of Antiretroviral Therapy in HIV-1 and HIV-2 Infected Patients, in Bamako, Mali.
| العنوان: | Comparing Treatment Outcomes of Antiretroviral Therapy in HIV-1 and HIV-2 Infected Patients, in Bamako, Mali. |
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| المؤلفون: | UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, Oumar, Aboubacar Alassane, Cissoko, Yacouba, Konaté, Issa, Kane, Adam, Dembélé, Jean Paul, Cissé, Mamadou, Murphy, Robert Leo, Yombi, Jean Cyr, Seydi, Moussa, Dao, Sounkalo, Maiga, Mamoudou |
| المصدر: | Current findings of infectious diseases, Vol. 2018, no.1, p. RD-INF-10003 [1-8] (2018) |
| بيانات النشر: | ReDelve International Publications LLC 2018 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND: HIV-2 leads to a less-severe disease than HIV-1 but is known to be resistant to Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs). We goaled to evaluate the clinical and biological outcomes of HIV-1 and HIV-2 infected-patients under Antiretroviral Therapy (ART) that do not include NNRTIs. METHODS: This is a case-control study of 100 participants (half in each group) to measure the frequency of clinical and biological adverse effects, and disease outcome at 6 and 12 months of treatment (M6 and M12) We included. RESULTS: Opportunistic infections were more frequent in HIV-1 infected patients with 82% when compared to HIV-2, 68%. However, the prevalence of treatment adverse events was slightly higher in HIV-2 infected patients. The average increase of CD4 cell count at M6 of treatment was 139.93 and 159.41 cells/mm3, for HIV-2 and HIV-1 groups respectively, and at 153 and 217 cells/mm3, at M12 for HIV-2 and HIV-1 respectively. A total of nine HIV-2 and six HIV-1 deaths were reported during the study. CONCLUSION: This study has shown that ART regimens that do not include NNRTIs are effective equally in the treatment of HIV-1 and HIV-2 infections. Nevertheless, we recommend regular and continuous laboratory monitoring for all HIV treated patients. |
| مصطلحات الفهرس: | ART, Adverse Effects Taxonomy Topics, HIV-1, HIV-2, Mali, info:eu-repo/semantics/article |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | English |
| Other Numbers: | UCDLC oai:dial.uclouvain.be:boreal:269880 boreal:269880 info:pmid/30627708 1372930703 |
| المصدر المساهم: | UNIVERSITE CATHOLIQUE DE LOUVAIN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1372930703 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |