Electronic Resource
Synthesis, Characterization, and Assessment of Anti-Cancer Potential of ZnO Nanoparticles in an In Vitro Model of Breast Cancer.
| العنوان: | Synthesis, Characterization, and Assessment of Anti-Cancer Potential of ZnO Nanoparticles in an In Vitro Model of Breast Cancer. |
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| المؤلفون: | Aljabali, Alaa A. A., Obeid, Mohammad A., Bakshi, Hamid A., Alshaer, Walhan, Ennab, Raed M., Al-Trad, Bahaa, Al Khateeb, Wesam, Al-Batayneh, Khalid M., Al-Kadash, Abdulfattah, Alsotari, Shrouq, Nsairat, Hamdi, Tambuwala, Murtaza M. |
| بيانات النشر: | MDPI |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Advanced innovations for combating variants of aggressive breast cancer and overcoming drug resistance are desired. In cancer treatment, ZnO nanoparticles (NPs) have the capacity to specifically and compellingly activate apoptosis of cancer cells. There is also a pressing need to develop innovative anti-cancer therapeutics, and recent research suggests that ZnO nanoparticles hold great potential. Here, the chemical effectiveness of ZnO NPs has been tested. Zinc oxide (ZnO) nanoparticles were synthesized using (L.) Schrad by green methods approach. The generated ZnO was observed to have a hexagonal wurtzite crystal arrangement. The generated nanomaterials were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), UV-visible spectroscopy. The crystallinity of ZnO was reported to be in the range 50-60 nm. The NPs morphology showed a strong absorbance at 374 nm with an estimated gap band of 3.20 eV to 3.32 eV. Microscopy analysis proved the morphology and distribution of the generated nanoparticles to be around 50 nm, with the elemental studies showing the elemental composition of ZnO and further confirming the purity of ZnO NPs. The cytotoxic effect of ZnO NPs was evaluated against wild-type and doxorubicin-resistant MCF-7 and MDA-MB-231 breast cancer cell lines. The results showed the ability of ZnO NPs to inhibit the prefoliation of MCF-7 and MDA-MB-231 prefoliation through the induction of apoptosis without significant differences in both wild-type and resistance to doxorubicin. |
| مصطلحات الفهرس: | H812 Pharmaceutical Engineering, A100 Pre-clinical Medicine, Article, PeerReviewed |
| URL: | 10.3390/molecules27061827 |
| الاتاحة: | Open access content. Open access content cc_by4 |
| ملاحظة: | application/pdf Aljabali, Alaa A. A., Obeid, Mohammad A., Bakshi, Hamid A., Alshaer, Walhan, Ennab, Raed M., Al-Trad, Bahaa, Al Khateeb, Wesam, Al-Batayneh, Khalid M., Al-Kadash, Abdulfattah, Alsotari, Shrouq, Nsairat, Hamdi and Tambuwala, Murtaza M. (2022) Synthesis, Characterization, and Assessment of Anti-Cancer Potential of ZnO Nanoparticles in an In Vitro Model of Breast Cancer. Molecules, 27 (6). ISSN 1420-3049 English |
| Other Numbers: | UKLIN oai:eprints.lincoln.ac.uk:53302 https://eprints.lincoln.ac.uk/id/eprint/53302/1/molecules-27-01827%20%281%29.pdf Aljabali, Alaa A. A., Obeid, Mohammad A., Bakshi, Hamid A., Alshaer, Walhan, Ennab, Raed M., Al-Trad, Bahaa, Al Khateeb, Wesam, Al-Batayneh, Khalid M., Al-Kadash, Abdulfattah, Alsotari, Shrouq, Nsairat, Hamdi and Tambuwala, Murtaza M. (2022) Synthesis, Characterization, and Assessment of Anti-Cancer Potential of ZnO Nanoparticles in an In Vitro Model of Breast Cancer. Molecules, 27 (6). ISSN 1420-3049 10.3390/molecules27061827 1372229612 |
| المصدر المساهم: | UNIV OF LINCOLN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1372229612 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |