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MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging

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العنوان: MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging
المؤلفون: Massachusetts Institute of Technology. Department of Biology, Schapiro, Denis, Sokolov, Artem, Yapp, Clarence, Chen, Yu-An, Muhlich, Jeremy L, Hess, Joshua, Creason, Allison L, Nirmal, Ajit J, Baker, Gregory J, Nariya, Maulik K, Lin, Jia-Ren, Maliga, Zoltan, Jacobson, Connor A, Hodgman, Matthew W, Ruokonen, Juha, Farhi, Samouil L, Abbondanza, Domenic, McKinley, Eliot T, Persson, Daniel, Betts, Courtney, Sivagnanam, Shamilene, Regev, Aviv, Goecks, Jeremy, Coffey, Robert J, Coussens, Lisa M, Santagata, Sandro, Sorger, Peter K
المصدر: Nature
بيانات النشر: Springer Science and Business Media LLC 2023-01-13T15:00:40Z 2023-01-13T15:00:40Z 2022 2023-01-13T14:37:17Z
نوع الوثيقة: Electronic Resource
مستخلص: AbstractHighly multiplexed tissue imaging makes detailed molecular analysis of single cells possible in a preserved spatial context. However, reproducible analysis of large multichannel images poses a substantial computational challenge. Here, we describe a modular and open-source computational pipeline, MCMICRO, for performing the sequential steps needed to transform whole-slide images into single-cell data. We demonstrate the use of MCMICRO on tissue and tumor images acquired using multiple imaging platforms, thereby providing a solid foundation for the continued development of tissue imaging software.
مصطلحات الفهرس: Article, http://purl.org/eprint/type/JournalArticle
URL: https://hdl.handle.net/1721.1/147096
10.1038/S41592-021-01308-Y
Nature Methods
الاتاحة: Open access content. Open access content
Creative Commons Attribution 4.0 International license
https://creativecommons.org/licenses/by/4.0
ملاحظة: application/pdf
English
Other Numbers: MYG oai:dspace.mit.edu:1721.1/147096
Schapiro, Denis, Sokolov, Artem, Yapp, Clarence, Chen, Yu-An, Muhlich, Jeremy L et al. 2022. "MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging." Nature Methods, 19 (3).
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المصدر المساهم: MASSACHUSETTS INST OF TECHNOL LIBRS
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رقم الانضمام: edsoai.on1370255936
قاعدة البيانات: OAIster
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