Electronic Resource
Plasma anandamide concentrations are lower in children with autism spectrum disorder
| العنوان: | Plasma anandamide concentrations are lower in children with autism spectrum disorder |
|---|---|
| المؤلفون: | Karhson, Debra S., Ahloy Dallaire, Jamie, Krasinska, Karolina M., Libove, Robin A., Phillips, Jennifer M., Chien, Allis S., Garner, Joseph P., Hardan, Antonio Y., Parker, Karen J. |
| بيانات النشر: | BioMed Central 2019-08-07T19:59:11Z 2019-08-07T19:59:11Z 2018-03-12 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Autism spectrum disorder (ASD) is a neurodevelopmentaldisorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD remain poorly understood, recent preclinical research has implicated the endogenous cannabinoid (or endocannabinoid), anandamide, as a significant neuromodulator in rodent models of ASD. Despite this promising preclinical evidence, no clinical studies to date have tested whether endocannabinoids are dysregulated in individuals with ASD. Here, we addressed this critical gap in knowledge by optimizing liquid chromatography-tandem mass spectrometry methodology to quantitatively analyze anandamide concentrations in banked blood samples collected from a cohort of children withand without ASD (N= 112). Findings: Anandamide concentrations significantly differentiated ASD cases (N= 59) from controls (N= 53), such that children with lower anandamide concentrations were more likely to have ASD (p= 0.041). In keeping with this notion, anandamide concentrations were also significantly lower in ASD compared to control children (p= 0.034). Conclusions: These findings are the first empirical human data to translate preclinical rodent findings to confirm a link between plasma anandamide concentrations in children with ASD. Although preliminary, these data suggest that impaired anandamide signaling may be involved in the pathophysiology of ASD. |
| مصطلحات الفهرس: | Anandamide, Autism spectrum disorder, Blood biomarker, Cannabinoid, Troubles du spectre de l'autisme chez l'enfant, Endocannabinoïdes, Marqueurs biologiques, Plasma, article de recherche, COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche |
| URL: | |
| الاتاحة: | Open access content. Open access content http://purl.org/coar/access_right/c_abf2 |
| ملاحظة: | application/pdf English |
| Other Numbers: | LVB oai:corpus.ulaval.ca:20.500.11794/35821 10.1186/s13229-018-0203-y 2040-2392 1369990639 |
| المصدر المساهم: | UNIVERSITE LAVAL From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1369990639 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |