Electronic Resource
Long-term results of robotic radiosurgery for non brachytherapy patients with cervical cancer
| العنوان: | Long-term results of robotic radiosurgery for non brachytherapy patients with cervical cancer |
|---|---|
| المؤلفون: | Morgenthaler, Janis, Koehler, Christhardt, Budach, Volker, Sehouli, Jalid, Stromberger, Carmen, Besserer, Angela, Trommer, Maike, Baues, Christian, Marnitz, Simone |
| بيانات النشر: | SPRINGER HEIDELBERG |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background Consolidation brachytherapy is a critical treatment component for cervical cancer patients undergoing primary chemoradiation. Some patients are unsuitable for brachytherapy for a variety of reasons. The use of alternatives (LINAC-based stereotactic radiosurgery or external beam boosts) compromise oncologic results in cervical cancer patients. Thus, we evaluated the value of brachytherapy-like doses prescriptions using robotic radiosurgery (CyberKnife (R), CR, Acuuray, Sunnyvale, CA, USA). Methods From 06/2011 to 06/2015, 31 patients (median age 53 years; range 30-77 years) with histologically proven FIGO stages IB-IVB cervical cancer underwent primary chemoradiation. All patients were either not suitable for intracervical brachytherapy for a variety of reasons or refused the brachytherapy. To achieve an adequate dose within the tumor, a CK boost was applied after fiducial implantation. In 29 patients, a dose of either five times 6Gy or five times 5Gy was prescribed to the target volume. Two patients received three times 5Gy. The target dose was prescribed to the 70% isodose. Treatment toxicity was documented once weekly regarding vaginal mucositis, bladder, and bowel irritation according to CTCAE v. 4.03. If possible 3 months after completion of treatment intracervical curettage was performed to exclude residual tumor and the patients were followed up clinically. Sparing of organs at risk (OAR) and outcome in terms of local control (LC), overall survival (OS), and progression-free survival (PFS) were assessed. Results Of the 31 patients, 30 have completed CK boost therapy. The median follow-up time was 40 months (range 5-84 months). General treatment tolerability was good. Except for 1 patient, who had diarrhea grade 3, no treatment related side effects above grade 2 were reported. Sparing of OAR was excellent. The 1-, 3-, and 5-year OS rates were 89, 60, and 57% respectively across all stages. Seven patients showed progression (28%), only two of them wit |
| مصطلحات الفهرس: | ddc:no, doc-type:article, publishedVersion |
| URL: | 10.1007/s00066-020-01685-x |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| Other Numbers: | K7U oai:USBKOELN.ub.uni-koeln.de:31837 Morgenthaler, Janis, Koehler, Christhardt, Budach, Volker, Sehouli, Jalid, Stromberger, Carmen, Besserer, Angela, Trommer, Maike, Baues, Christian and Marnitz, Simone . Long-term results of robotic radiosurgery for non brachytherapy patients with cervical cancer. Strahlenther. Onkol.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X 1364931115 |
| المصدر المساهم: | UNIVERSITATS- UND STADTBIBLIOTHEK KOLN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1364931115 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |