Electronic Resource
Recommendations for clinical decision-making in children with type 1 diabetes and celiac disease: type 1 diabetes and celiac disease joint working group report
| العنوان: | Recommendations for clinical decision-making in children with type 1 diabetes and celiac disease: type 1 diabetes and celiac disease joint working group report |
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| المؤلفون: | Hatun, Şükrü (ORCID 0000-0003-1633-9570 & YÖK ID 153504); Mutlu, Gül Yeşiltepe (ORCID 0000-0003-3919-7763 & YÖK ID 153511); Kızılkan, Nuray Uslu (ORCID 0000-0002-1098-9604 & YÖK ID 221274); Taşkın, Orhun Çığ (ORCID 0000-0002-6668-3006 & YÖK ID 166686), Dalgıç, B.; Gökşen, D.; Aydoğdu, S.; Savaş, Erdeve Ş.; Kuloğu, Z.; Doğan, Y.; Aycan, Z.; Keser, A.; Beşer, Ö.F.; Özbek, M.N.; Bideci, A.; Ertem, D.; Evliyaoğlu, O.; Eliüz Tipici, B.; Gökçe, T.; Muradoğlu, S.; Koca, T.; Tütüncüler, F.; Baş, F.; Darendeliler, F.; Selimoğlu, M.A., Koç University Hospital, School of Medicine |
| المصدر: | Journal of Clinical Research in Pediatric Endocrinology |
| بيانات النشر: | Galenos Yayınevi National 2022 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | It is well-known that in children with type 1 diabetes (T1D), the frequency of Celiac disease (CD) is increased due to mechanisms which are not fully elucidated but include autoimmune injury as well as shared genetic predisposition. Although histopathologic examination is the gold standard for diagnosis, avoiding unnecessary endoscopy is crucial. Therefore, for both clinicians and patients’ families, the diagnosis of CD remains challenging. In light of this, a joint working group, the Type 1 Diabetes and Celiac Disease Joint Working Group, was convened, with the aim of reporting institutional data and reviewing current international guidelines, in order to provide a framework for clinicians. Several controversial issues were discussed: For CD screening in children with T1D, regardless of age, it is recommended to measure tissue transglutaminase-immunoglobulin A (tTG-IgA) and/or endomysial-IgA antibody due to their high sensitivity and specificity. However, the decision-making process based on tTG-IgA titer in children with T1D is still debated, since tTG-IgA titers may fluctuate in children with T1D. Moreover, seronegativity may occur spontaneously. The authors’ own data showed that most of the cases who have biopsy-proven CD had tTG-IgA levels 7-10 times above the upper limit. The decision for endoscopy based solely on tTG-IgA levels should be avoided, except in cases where tTG-IgA levels are seven times and above the upper limit. A closer collaboration should be built between divisions of pediatric endocrinology and gastroenterology in terms of screening, diagnosis and follow-up of children with T1D and suspicious CD. NA |
| مصطلحات الفهرس: | Endocrinology and metabolism; Pediatrics, Anti-tissue transglutaminase-IgA; Celiac disease; Children; Type 1 diabetes, Journal article, text/academic publication |
| URL: | Publisher version Koç University Institutional Repository |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | pdf English |
| Other Numbers: | T9K oai:libdigitalcollections.ku.edu.tr:IR/10419 IR03561.pdf 1308-5735 1308-5735 Hatun, Sukru, Buket Dalgic, Damla Goksen, Sema Aydogdu, Erdeve S. Savas, Zarife Kuloglu, Yasar Dogan, Zehra Aycan, Mutlu G. Yesiltepe, Kızılkan N. Uslu, Alev Keser, Omer F. Beser, Mehmet N. Ozbek, Aysun Bideci, Deniz Ertem, Olcay Evliyaoglu, Tipici B. Eliuz, Tugba Gokce, Serra Muradoglu, Orhun C. Taskin, Tugba Koca, Filiz Tutunculer, Firdevs Bas, Feyza Darendeliler, and Mukadder A. Selimoglu. ""Recommendations for Clinical Decision-Making in Children with Type 1 Diabetes and Celiac Disease: Type 1 Diabetes and Celiac Disease Joint Working Group Report."" Journal of Clinical Research in Pediatric Endocrinology. 14.1 (2022): 1-9. WoS; Scopus; PubMed; TR Dizin NA NA 1360591725 |
| المصدر المساهم: | KOC UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1360591725 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |