Electronic Resource
The social and genetic epidemiology of Hepatitis C in an isolated network of people who inject drugs
| العنوان: | The social and genetic epidemiology of Hepatitis C in an isolated network of people who inject drugs |
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| المؤلفون: | Buchanan, Ryan Malcolm. |
| بيانات النشر: | University of Southampton 2017-12 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background and Aims Hepatitis C (HCV) causes liver cirrhosis, liver cancer and is a leading cause of death worldwide. In the UK the commonest risk factor for HCV is current or previous injecting drug use but many cases are undiagnosed and many known cases are disengaged from treatment services. The Isle of Wight (IOW) is a deprived, rural and geographically isolated population but suffers from the same obstacles to HCV care as larger nearby mainland populations. The overall aim of this thesis is to understand the burden of HCV in people who inject drugs (PWID) on the IOW and how their social network could be utilised in an HCV elimination strategy. Method A sequential mixed method research design was used. Qualitative methods informed the design of a quantitative survey, which recruited PWID via respondent driven sampling (RDS) for a social network questionnaire and HCV bio-behavioural survey. This was used to estimate the population prevalence of HCV and the total population size of PWID on the IOW. Data from the social network survey were combined with a phylogenetic analysis of HCV RNA positive cases and qualitative narratives to give a representation of the HCV transmission network in PWID. This network was then used in an individualbased model (IBM) testing different treatment strategies. Results Sixty-nine PWID participated in the HCV bio-behavioural and social network surveys. The estimated prevalence of HCV was 29% (95% CI 13.3-44%) and the estimated total population size was 262 individuals. The social network survey described 179 PWID, connected together into a cohesive network component via injecting partnerships. Phylogenetic analysis indicated that a number of these partnerships had led to the transmission of HCV and that genotype 3a virus had been transmitted between PWID living on the IOW. In the IBM the preferential treatment of well-connected PWID, via injecting and socia |
| مصطلحات الفهرس: | Thesis, NonPeerReviewed |
| URL: | |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | University of Southampton Doctoral Theses |
| Other Numbers: | S2H oai:eprints.soton.ac.uk:417993 1359208478 |
| المصدر المساهم: | UNIV OF SOUTHAMPTON, HARTLEY LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1359208478 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |