Electronic Resource
Brain sex-dependent alterations after prolonged high fat diet exposure in mice
| العنوان: | Brain sex-dependent alterations after prolonged high fat diet exposure in mice |
|---|---|
| المؤلفون: | Murtaj, V, Penati, S, Belloli, S, Foti, M, Coliva, A, Papagna, A, Gotti, C, Toninelli, E, Chiaffarelli, R, Mantero, S, Pucci, S, Matteoli, M, Malosio, M, Moresco, R, Murtaj, Valentina, Penati, Silvia, Belloli, Sara, Foti, Maria, Coliva, Angela, Papagna, Angela, Gotti, Cecilia, Toninelli, Elisa, Chiaffarelli, Remy, Mantero, Stefano, Pucci, Susanna, Matteoli, Michela, Malosio, Maria Luisa, Moresco, Rosa Maria |
| بيانات النشر: | Nature Publishing Group country:GB 2022 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | We examined effects of exposing female and male mice for 33 weeks to 45% or 60% high fat diet (HFD). Males fed with either diet were more vulnerable than females, displaying higher and faster increase in body weight and more elevated cholesterol and liver enzymes levels. Higher glucose metabolism was revealed by PET in the olfactory bulbs of both sexes. However, males also displayed altered anterior cortex and cerebellum metabolism, accompanied by a more prominent brain inflammation relative to females. Although both sexes displayed reduced transcripts of neuronal and synaptic genes in anterior cortex, only males had decreased protein levels of AMPA and NMDA receptors. Oppositely, to anterior cortex, cerebellum of HFD-exposed mice displayed hypometabolism and transcriptional up-regulation of neuronal and synaptic genes. These results indicate that male brain is more susceptible to metabolic changes induced by HFD and that the anterior cortex versus cerebellum display inverse susceptibility to HFD. |
| مصطلحات الفهرس: | high fat diet, brain, sex, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/36414721 info:eu-repo/semantics/altIdentifier/wos/WOS:000887945000002 volume:5 issue:1 journal:COMMUNICATIONS BIOLOGY |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | ELETTRONICO English |
| Other Numbers: | ITBAO oai:boa.unimib.it:10281/397467 10.1038/s42003-022-04214-x info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85142304938 1358884600 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1358884600 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |